- HMHV-1B18 (See other available formats)
- Regulatory Status
- Other Names
- Herpes virus entry mediator, TR2, tumor necrosis factor receptor like 2, TNFRSF14, HVEM
- Armenian hamster IgG
- Ave. Rating
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- Product Citations
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Herpes Virus Entry Mediator (HVEM, TR2) is a type I transmembrane protein of TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HAS) entry. Binding of HSV viral envelope glycoprotein D to this receptor has been shown to be part of the viral entry mechanism. It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs. The ligands of HVEM are LIGHT, BTLA, LTα, and CD160. HVEM activates NF-kB through the TNF-related cytokine LIGHT to serve as a costimulatory pathway during T cell activation. HVEM also functions as a ligand for the Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160 to deliver a coinhibitory signal and limit inflammatory responses initiated by T cells. HVEM plays an important role in regulating lymphocyte activation and homeostasis in immune responses.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- Mouse HVEM-hIgG1Fc fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_1967134 (BioLegend Cat. No. 136302)
- A type I transmembrane protein of TNF-receptor superfamily.
It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs.
- Play an important role in regulating lymphocyte activation and homeostasis in immune responses.
- LIGHT, BTLA, LTα, CD160
- Cell Type
- B cells, Dendritic cells, Neutrophils
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Signal Transduction
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Fan Z, et al. 2006. Blood 107(4):1342
2. Granger SW, et al. 2008. Stem Cells. 27:653
3. Kwon BS, et al. 1997. J. Biol. Chem. 272:13471
4. Gonzalez LC, et al. 2005. Proc. Nat. Acad. Sci. U. S. A. 102:1116
5. Montgomery RI, et al. 1996. Cell. 87:427
6. Cheung TC, et al. 2009. Proc. Nat. Acad. Sci. U. S. A. 106 (15):6244
7. Cai G, et al. 2009. Immunol. Rev. 229(1):244
- Gene ID
- 230979 View all products for this Gene ID
- View information about CD270 on UniProt.org
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