- A17071D (See other available formats)
- Other Names
- IL-1 Rrp, CDw218a, IL-18 receptor a
- Rat IgG2b, κ
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- Product Citations
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The IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor α (IL-18Rα) and IL-18 receptor β (IL-18Rβ). IL-18Rα (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family. IL-18Rα is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4+ T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Rα is induced by an IL-12/Stat4 pathway and inhibited by IL-4/Stat6 pathway. Binding of IL-18Rα together with IL-18β to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.Product Details
- Antibody Type
- Host Species
- Recombinant mouse CD218a
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- An IL-1 receptor super family member
Expressed on T cells, NK cell subset, neutrophils, IL-12 stimulated tonsillar B cells, and intestinal epithelial cells (IEC).
- Bind to pro inflammatory cytokine IL-18 and play an important role in innate and autoimmune responses.
- Cell Type
- B cells, Endothelial cells, Neutrophils, NK cells, T cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
- Parnet P, et al. 1996. J. Biol. Chem. 271:3967.
- Thomassen E, et al. 1998. J. Interferon Cytokine Res. 18:1077-88.
- Debets R, et al. 2000. J. Immunol. 165:4950-6.
- Smeltz RB, et al. 2001. J. Exp. Med. 194:143-53.
- Gene ID
- 16182 View all products for this Gene ID
- View information about CD218a on UniProt.org
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