Purified anti-mouse CD218a (IL-18Rα) Antibody

Pricing & Availability
Clone
A17071D (See other available formats)
Other Names
IL-1 Rrp, CDw218a, IL-18 receptor a
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
A17071D_PURE_CD218a_Antibody_072419
C57BL/6 splenocytes were stained with CD3 PE and purified CD218a (IL-18Rα) (clone A17071D, left) or purified rat IgG2b, κ (right), followed by anti-rat IgG Alexa Fluor® 647.
  • A17071D_PURE_CD218a_Antibody_072419
    C57BL/6 splenocytes were stained with CD3 PE and purified CD218a (IL-18Rα) (clone A17071D, left) or purified rat IgG2b, κ (right), followed by anti-rat IgG Alexa Fluor® 647.
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157902 500 µg £262
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Description

The IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor α (IL-18Rα) and IL-18 receptor β (IL-18Rβ). IL-18Rα (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family. IL-18Rα is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4+ T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Rα is induced by an IL-12/Stat4 pathway and inhibited by IL-4/Stat6 pathway. Binding of IL-18Rα together with IL-18β to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse CD218a
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
An IL-1 receptor super family member
Distribution

Expressed on T cells, NK cell subset, neutrophils, IL-12 stimulated tonsillar B cells, and intestinal epithelial cells (IEC).

Function
Bind to pro inflammatory cytokine IL-18 and play an important role in innate and autoimmune responses.
Ligand/Receptor
IL-18
Cell Type
B cells, Endothelial cells, Neutrophils, NK cells, T cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References
  1. Parnet P, et al. 1996. J. Biol. Chem. 271:3967. 
  2. Thomassen E, et al. 1998. J. Interferon Cytokine Res. 18:1077-88. 
  3. Debets R, et al. 2000. J. Immunol. 165:4950-6. 
  4. Smeltz RB, et al. 2001. J. Exp. Med. 194:143-53. 
Gene ID
16182 View all products for this Gene ID
UniProt
View information about CD218a on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 07/24/2019

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