Purified anti-mouse CD20 Recombinant Antibody, CD20, QA18A73

Pricing & Availability

Clone: QA18A73 (See other available formats)
Regulatory Status: RUO
Other Names: Ms4a1, Ly-44
Isotype: Mouse IgG2a, κ
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Product Citations: publications

QA18A73_PURE_CD20_Antibody_020521 — C57BL/6 mouse splenocytes were stained with anti-mouse/human CD45R/B220 APC and purified anti-mouse CD20 recombinant (clone QA18A73) (left) or purified anti-mouse IgG2a, κ isotype control (right), followed by anti-mouse IgG2a PE.

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161402

500 µg

£189

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Description

CD20 is a 33-37 kD protein, a member of the MS4A family, with four transmembrane spanning regions that present as a homo-oligomeric complexes in the cell surface when associating with MHC class I and II, CD53, CD81, and CD82. CD20 is expressed on B cells and a subset of T cells, but not on plasma cells. CD20 regulates B-cell activation and proliferation. Its ligation promotes transmembrane Ca2+ trafficking. CD20 is an important therapeutic target in the treatment of B cell lymphomas and leukemias.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Recombinant
Host Species: Mouse
Immunogen: Mouse CD20 transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This recombinant antibody clone is derived from clone SA271G2.
RRID: AB_2890726 (BioLegend Cat. No. 161402)

Antigen Details

Structure: Member of the MS4A family, four transmembrane spanning regions, three isoforms of 37, 35, and 37 kD, depending on the phosphorylation degree.
Distribution: B cells and a subset of T cells
Function: Regulates B-cell activation and proliferation
Interaction: Associates with MHC class I and II, CD53, CD81, and CD82
Antigen References: 1. Morsy DE, et al. 2013. J. Immunol. 191:3112.
2. Pang X, et al. 2017. Hum Gene Ther. 28(2):216-225.
3. Uchida J, et al. 2004. Int Immunol. 16(1):119-29
Gene ID: 12482 View all products for this Gene ID
UniProt: View information about CD20 on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD20 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse CD20 Recombinant Antibody	QA18A73	FC
APC anti-mouse CD20 Recombinant Antibody	QA18A73	FC
PE anti-mouse CD20 Recombinant Antibody	QA18A73	FC
Ultra-LEAF™ Purified anti-mouse CD20 Recombinant Antibody	QA18A73	FC,Depletion
FITC anti-mouse CD20 Recombinant Antibody	QA18A73	FC

Certificate of Analysis

Go To Top Version: 2 Revision Date: 03/26/2021

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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