Purified anti-mouse CD126 (IL-6Rα) Antibody

Pricing & Availability
W18166A (See other available formats)
Regulatory Status
Other Names
Interluekin 6 receptor alpha, CD126
Rat IgG2a, κ
Ave. Rating
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Product Citations
C57BL/6 splenocytes were stained with CD3 FITC, CD4 PerCP/Cyanine5.5, and purified CD126 (IL-6Rα) (clone W18166A) (left) or rat IgG2a, κ isotype control (right), followed by anti-rat IgG PE. Dot plots are gated on CD3 positive cells
  • W18166A_PURE_CD169_Antibody_1_072320
    C57BL/6 splenocytes were stained with CD3 FITC, CD4 PerCP/Cyanine5.5, and purified CD126 (IL-6Rα) (clone W18166A) (left) or rat IgG2a, κ isotype control (right), followed by anti-rat IgG PE. Dot plots are gated on CD3 positive cells
  • W18166A_PURE_CD169_Antibody_2_072320
    Blocking of IL-6/STAT3 signaling pathway was assessed by intracellular staining of C57BL/6 splenocytes with STAT3 pY705 PE. Cells were incubated with purified CD126 (clone W18166A) or isotype control for 15 minutes, then treated with IL-6. Mean fluorescence intensity (MFI) of STAT3 pY705 PE were gated on CD4 positive cells.
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160402 500 µg £338
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CD126 (IL-6Rα) is an 80kD member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Mouse IL-6R recombinant protein, 1-357 a.a.
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
The antibody was purified by affinity chromatography.
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested
Block - Verified

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone W18166A binds to IL-6 receptor alpha, inhibits IL-6/IL-6 receptor interaction and mediated phosphorylation of signal transducer and activator of transcription 3 (STAT3). This clone does not cross-react with rat.

AB_2876570 (BioLegend Cat. No. 160402)

Antigen Details

Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD

T cells and activated B cells, monocytes, hepatocytes, plasma cells

Stimulates T cells, B cells, hematopoietic precursor proliferation and differentiation
Cell Type
B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

Taga T, et al. 1997. Annu Rev Immunol. 15:797-819.

Fitzgerald K, et al. 2001. The Cytokine FactsBook. Academic Press London.

Boulanger MJ, et al. 2003. Science. 300:2101-4

Gene ID
16194 View all products for this Gene ID
View information about CD126 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 07/17/2020

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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  • Purified anti-mouse CD126 (IL-6Rα)

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