- QA17A24 (See other available formats)
- Other Names
- Integrin αIEL chain, Integrin αE chain, αE integrin, ITGAE
- Mouse IgG1, κ
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- Product Citations
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CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.Product Details
- Antibody Type
- Host Species
- Mouse intestinal intraepithelial lymphocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Type I transmembrane glycoprotein, Integrin family, can be cleaved into 150 kD and 25 kD chains, associated with β7 integrin
- Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulate tissue-specific T cell homing.
- T cells, Dendritic cells, Lymphocytes, Tregs
- Cell Type
- Dendritic cells, Lymphocytes, T cells, Tregs
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
- Kilshaw PJ and Murant SJ. 1990. Eur. J. Immunol. 20:2201.
- Karecla PI, et al. 1995. Eur. J. Immunol. 25:852.
- LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635.
- Sung SS, et al. 2006. J. Immunol. 176:2161.
- Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063.
- Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.
- Gene ID
- 16407 View all products for this Gene ID
- View information about CD103 on UniProt.org
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