Purified anti-mouse CD103 Recombinant Antibody

Pricing & Availability
Clone
QA17A24 (See other available formats)
Other Names
Integrin αIEL chain, Integrin αE chain, αE integrin, ITGAE
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA17A24_Purified_CD103_Antibody_051419.png
C57BL/6 Splenocytes were stained with purified anti-mouse CD103 (clone QA17A24) (left) or purified mouse IgG1, κ isotype control (right) followed by FITC rat anti-mouse IgG1 and CD3 APC.
  • QA17A24_Purified_CD103_Antibody_051419.png
    C57BL/6 Splenocytes were stained with purified anti-mouse CD103 (clone QA17A24) (left) or purified mouse IgG1, κ isotype control (right) followed by FITC rat anti-mouse IgG1 and CD3 APC.
Cat # Size Price Quantity Avail. Save
156902 500 µg £185
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Description

CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Recombinant
Host Species
Mouse
Immunogen
Mouse intestinal intraepithelial lymphocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
Type I transmembrane glycoprotein, Integrin family, can be cleaved into 150 kD and 25 kD chains, associated with β7 integrin
Function
Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulate tissue-specific T cell homing.
Interaction
T cells, Dendritic cells, Lymphocytes, Tregs
Ligand/Receptor
E-Cadherin
Cell Type
Dendritic cells, Lymphocytes, T cells, Tregs
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Kilshaw PJ and Murant SJ. 1990. Eur. J. Immunol. 20:2201.
  2. Karecla PI, et al. 1995. Eur. J. Immunol. 25:852.
  3. LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635.
  4. Sung SS, et al. 2006. J. Immunol. 176:2161.
  5. Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063.
  6. Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.
Gene ID
16407 View all products for this Gene ID
UniProt
View information about CD103 on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 05/14/2019

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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