Purified anti-MMP3 Antibody

Pricing & Availability
Clone
F36P1B4 (See other available formats)
Regulatory Status
RUO
Other Names
Progelatinase, STR1, Transin, Stromelysin I, MMP-3
Isotype
Mouse IgG1, λ
Ave. Rating
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Product Citations
publications
MMP-3_WB
Western blot analysis of recombinant human MMP-3 protein using anti-MMP-3, clone F36P1B4.
  • MMP-3_WB
    Western blot analysis of recombinant human MMP-3 protein using anti-MMP-3, clone F36P1B4.
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634902 100 µg £133.00
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Description

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances withinthe extracellular matrix. The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs, plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I, II, III, VII and X.MMP1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction. Clone F15P3B6 has been shown to be useful for western blotting and immunohistochemistry of human MMP1.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Ovalbumin-conjugated synthetic peptide CKSLRKLEPELH
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested
IHC-P, ELISA - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 4 µg/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Murray G et al. 1998. Gut. 43:791.
  2. Cheng Z, et al. 2011. Eur J Pharmacol. 664:20. PubMed.
Product Citations
  1. Cheng Z, et al. 2011. Eur J Pharmacol. 664:20. PubMed
RRID
AB_2146594 (BioLegend Cat. No. 634902)

Antigen Details

Structure
Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains, predicted molecular weight approximately 54 kD.
Distribution

Extracellular

Function
MMP3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. MMP-3 is thought to play a prominent role in the pathogenesis of rheumatoid arthritis.
Interaction
MCP1-4, TIMP1, TIMP3, Decorin, Testican 3, Plasminogen, Aggrecan 1, Osteopontin, IBP-3
Biology Area
Angiogenesis, Cell Adhesion, Cell Biology, Neuroinflammation, Neuroscience
Molecular Family
Enzymes and Regulators
Antigen References

1. Saus J, et al. 1988. J. Biol. Chem. 263:6742

Gene ID
4314 View all products for this Gene ID
UniProt
View information about MMP-3 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 10/29/2021

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