- N382/14 (See other available formats)
- Regulatory Status
- Other Names
- Mitochondrial Fission Factor, C2orf33, Chromosome 2 Open Reading Frame 33, EMPF2, GL004
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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Mitochondrial fission factor (MFF) is a mitochondrion outer membrane protein that is part of the mitochondrial fission complex where it acts a receptor for the dynamin-related protein 1 (Drp1). The MFF-Drp1 complex is responsible for the promotion of mitochondrial fission. MFF has also been shown to regulate peroxisome morphology.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Fusion protein including amino acids 1-173 and 272-322 of human MFF
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2783475 (BioLegend Cat. No. 857501)
AB_2783476 (BioLegend Cat. No. 857502)
- MFF is a 342 amino acid protein with a molecular mass of ~38 kD.
Tissue Distribution: Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
Cellular Distribution: Mitochondria, peroxisome, nucleus, and cytosol.
- MFF plays a role in mitochondrial and peroxisomal fission by facilitating the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
- MFF interacts with the dynamin-related protein 1 (Drp1). MFF has also been shown to interact with DDX28 and ILF3.
- Biology Area
- Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience
- Molecular Family
- Organelle Markers
- Antigen References
- Moon Yong Cha, et al. 2018. PLoS Curr. 26;10.
- Kornfeld OS, et al. 2018. Sci Rep. 19;8(1):14034.
- Otera H, et al. 2010. J Cell Biol. 13;191(6):1141-58.
- Liu R, et al. 2015. Mol Biol Cell. 1;26(24):4466-77.
- Gene ID
- 56947 View all products for this Gene ID
- View information about MMF on UniProt.org
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