- B11F7 (See other available formats)
- Regulatory Status
- Other Names
- Siglec-4a, Myelin-associated Glycoprotein,
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Myelin-associated glycoprotein (MAG) is a cell membrane glycoprotein and a member of the siglec (sialic acid-binding immunoglobulin-like lectins) family. MAG has two isoforms in myelinated structures in the nervous system. MAG is expressed on oligodendrocytes and Schwann cells and is believed to be involved in myelination during nerve regeneration. MAG knockout mice develop quite severe pathological abnormalities associated with myelin instability.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Purified MAG protein isolated from human central nervous system.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Dobersen MJ, et al. 1985. Neurochem Research. 4: 499 (WB and IHC)
- Cao Z, et al. 2007. J Neurosci. 34: 9146 (WB)
AB_2749879 (BioLegend Cat. No. 851701)
AB_2749880 (BioLegend Cat. No. 851702)
- MAG is a 626 amino acid protein with a molecular mass of 70 kD.
Tissue distribution: Central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures.
Cellular distribution: Plasma membrane
- MAG is involved in the process of axon myelination and maintenance of myelin sheath along axons. MAG also functions as a receptor that promotes differentiation, maintenance and survival of oligodendrocytes. Aberrant immunoreactivity to MAG has been suggested to play a role in the pathogenesis of multiple sclerosis.
- MAG binds to neuronal sialic acid-containing gangliosides and to glycoproteins RTN4R and RTN4RL2.
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Siglec Molecules
- Antigen References
- Dobersen MJ, et al. 1985. Neurochem Research. 4: 499
- McKerracher L and Rosen KM. 2015. Front Mol Neurosci. 8: 51
- Vallat JM, et al. 2016. Expert Rev Neurother. 9: 1111
- Gene ID
- 4099 View all products for this Gene ID
- View information about MAG on UniProt.org
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