- Poly19055 (See other available formats)
- Other Names
- Keratin, type II cytoskeletal 5, CK-5, 58 kda cytokeratin, type-II keratin Kb5, epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types, keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types), krt5
- Rabbit Polyclonal IgG
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- Product Citations
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Keratin 5 is a member of the type II (basic or neutral) cytokeratin family. Type II keratins, in general, are heteropolymeric structural proteins coexpressed during differentiation of simple and stratified epithelial tissues. Keratin 5 is specifically expressed in the basal layer of the epidermis along with Keratin 14.Product Details
- Human, Mouse, Rat, Cross Reactivity: Dog, Primate
- Antibody Type
- Host Species
- This monospecific polyclonal antibody was raised against a peptide sequence derived from the C-terminus of the mouse keratin 5 protein.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
WB, ICC - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemisty, a concentration range of 0.2 - 5.0 μg/ml is suggested. For Western blotting, a concentration range of 0.5 - 1.0 μg/ml is suggested. For immunocytochemistry, a concentration range of 0.5 - 1.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Predicted MW is ~ 62 kD. This antibody weakly reacts with mouse.
This product may contain other non-IgG subtypes.
(PubMed link indicates BioLegend citation)
- Hübner A, et al. 2012. Proc. Natl. Acad. Sci. USA 109:12046. (IHC) PubMed
- Kierszenbaum AL, et al. 2003. Mol. Biol. Cell 14(11):4628. (IHC) PubMed
- Hu Y, et al. 2001. Nature 410:710.
- Yuspa SH, et al. 1989. J. Cell Biol. 109:1207.
- Liang Y. 2011. Patholog. Res. Int. 2011:936794. (IHC) PubMed
- Roop DR, et al. 1984. J. Biol. Chem. 259:8037.
- Product Citations
AB_2734679 (BioLegend Cat. No. 905503)
AB_2616956 (BioLegend Cat. No. 905504)
- Keratin 5 is a 62 kD protein.
Cytoskeleton, extracellular, and nucleus.
- Keratin 5 mutations have been associated with a complex of diseases termed epidermolysis bullosa simplex.
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Intermediate Filaments
- Gene ID
- 3852 View all products for this Gene ID
- View information about Keratin 5 on UniProt.org
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