Purified anti-human uPA (PLAU) Antibody

Pricing & Availability
Clone
UK98/6 (See other available formats)
Other Names
Urokinase-type Plasminogen activator, urokinase, Plasminogen activator, ATF, BDPLT5, QPD, UPA, URK
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
UK98slash6_Pure_u-PA_120715
NCI-H1299 cells (a non-small cell lung cancer cell line) were stained with purified uPA (clone UK98/6) (filled histogram) or purified mouse IgG1, κ isotype control, followed by anti-mouse IgG PE.
  • UK98slash6_Pure_u-PA_120715
    NCI-H1299 cells (a non-small cell lung cancer cell line) were stained with purified uPA (clone UK98/6) (filled histogram) or purified mouse IgG1, κ isotype control, followed by anti-mouse IgG PE.
Cat # Size Price Quantity Avail. Save
369002 100 µg £154
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Description

uPA is a serine protease. It is produced as a single-chain protein containing serine protease domain, Kringle domain, and growth factor domain. It is proteolyticaly cleaved between Lys158 and Ile159; the two resulting chains are kept together as a dimer by a disulfide bond. The primary function of uPA is to convert plasminogen into plasmin by specific cleavage of an Arg-Val bond in plasminogen. uPA is also involved in the degradation of the extracellular matrix and possibly tumor cell migration and proliferation. Alternatively spliced transcript variants encoding different isoforms have been found for uPA; a specific polymorphism of uPA may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Purified urokinase
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
ICC, IHC - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Heidtmann H, et al. 1989. Cancer Research 49:6960.
  2. Schwartz-Albiez R, et al. 1992. Br. J. Cancer 65:51.
RRID
AB_2566427 (BioLegend Cat. No. 369002)

Antigen Details

Structure
411-aa residue zymogen that is cleaved into two chains and forms heterodimer.
Distribution

Urine, blood, and extracellular matrix.

Function
Serine protease.
Ligand/Receptor
u-PA Receptor, CD87.
Biology Area
Cell Adhesion, Cell Biology, Immunology
Antigen References

1. Riccio A, et al. 1985. Nucleic Acids Res. 13:2759.

Gene ID
5328 View all products for this Gene ID
UniProt
View information about uPA on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 01/21/2021

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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