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Purified anti-human TCR Vα24-Jα18 (iNKT cell) Antibody

Pricing & Availability
Clone
6B11 (See other available formats)
Regulatory Status
RUO
Other Names
TCR Vα24-Jα18, TCR Vα24-JαQ, invariant NKT cell, iNKT
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
A_6B11_PE_070609.jpg
Human peripheral blood lymphocytes stained with purified 6B11 conjugated to PE and CD3 (UCHT1) Alexa Fluor® 647 (top) or mIgG1, κ (MOPC-21) PE isotype control and CD3 (UCHT1) Alexa Fluor® 647 (bottom)
  • A_6B11_PE_070609.jpg
    Human peripheral blood lymphocytes stained with purified 6B11 conjugated to PE and CD3 (UCHT1) Alexa Fluor® 647 (top) or mIgG1, κ (MOPC-21) PE isotype control and CD3 (UCHT1) Alexa Fluor® 647 (bottom)
  • B_6B11_PE_070609.jpg
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342902 100 µg £85
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Description

Encoded by the TCR Vα24-Jα18 germline configuration, Vα24-JαQ is expressed on a subset of NKT cells, namely invariant NKT (iNKT). Vα24-JαQ TCR interacts with the glycolipid loaded MHC class 1b molecule CD1d, inducing activation and subsequent cytokine production. iNKT cells have been implicated in immune regulation, tumor surveillance, and host response to pathogens. While iNKT cells occur at low frequency in the blood, assorted chemokines contribute to their tissue homing potential.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Rhesus, Pigtailed Macaque, Sooty Mangabey
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The 6B11 antibody recognizes the invariant CDR3 region of TCR Va24-JaQ.

Application References

(PubMed link indicates BioLegend citation)
  1. Rout N, et al. 2010. PLoS One 5:e9787. (FC)
Product Citations
  1. Nugent JL, et al. 2021. iScience. 24:103421. PubMed
  2. Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed
  3. Speir M,et al. 2017. Sci Rep.. 10.1038/s41598-017-14690-5. PubMed
  4. Schwabenland M, et al. 2021. Immunity. . PubMed
  5. Melo AM, et al. 2020. Cancer Immunol Immunother. 69:969. PubMed
  6. Martin E, et al. 2020. JCI Insight. :5. PubMed
RRID
AB_2229301 (BioLegend Cat. No. 342902)

Antigen Details

Structure
Invariant CDR3 region of TCR Vα24-JαQ
Distribution

Invariant NKT cells

Ligand/Receptor
Glycolipid loaded CD1d
Cell Type
NKT cells
Biology Area
Immunology
Molecular Family
TCRs
Antigen References
  1. Thomas SY, et al. 2003. J. Immunol. 171:2571.
  2. Exley MA, et al. 2008. Eur. J. Immunol. 38:1756.
  3. Montoya CJ, et al. 2007. Immunology. 122:1.
  4. Gansuvd B, et al. 2003. J. Immunol. 171:2904.
Gene ID
28659 View all products for this Gene ID
UniProt
View information about TCR Valpha24-Jalpha18 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 3    Revision Date: 08/30/2022

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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