- QA18A24 (See other available formats)
- Regulatory Status
- Other Names
- T-box expressed in T cells, T box 21, TBLYM
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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T-bet, also known as T-box transcription factor T-bet, is considered to be a "master regulator" of Th1 lymphoid development controlling the production of the cytokine IFN-γ. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens, and knockout animals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimally observed after IL-12 stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL-12.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone QA18A24 can completely block the binding of clone 4B10 on target cells.
AB_2904398 (BioLegend Cat. No. 365902)
- T-box transcription factor, approximately 58 kD.
Nuclear; expressed in T cells, hematopoietic stem cells, NK cells, B cells, lung, spleen.
- Th1-specific T-box transcription factor controlling expression of the hallmark Th1 cytokine, interferon gamma (IFN-γ). T-bet expression is critical for the control of microbial pathogens.
- Cell Type
- B cells, Hematopoietic stem and progenitors, NK cells, T cells, Tregs
- Biology Area
- Cell Biology, Immunology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
- Szabo SJ, et al. 2000. Cell. 100:655-69.
- Szabo SJ, et al. 2002. Science. 295:338-42.
- Finotto S, et al. 2002. Science. 295:336-8.
- Mullen AC, et al. 2001. Science. 292:1907-10.
- Gene ID
- 30009 View all products for this Gene ID
- View information about T-bet on UniProt.org
|Purified anti-human T-bet Recombinant Antibody||QA18A24||ICFC|
|PE anti-human T-bet Recombinant Antibody||QA18A24||ICFC|
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