Purified anti-human FcμR (FAIM3) Antibody

Pricing & Availability
Clone
HM7 (See other available formats)
Other Names
FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
HM7_PURE_FCmuR_Antibody_081219.png
Human peripheral blood lymphocytes were stained with FcμR (FAIM3) (clone HM7) Purified (left) or Mouse IgG2a, κ Purified isotype control (right) followed by PE anti-mouse IgG. Cells were then stained with CD19 PerCP/Cyanine5.5.
  • HM7_PURE_FCmuR_Antibody_081219.png
    Human peripheral blood lymphocytes were stained with FcμR (FAIM3) (clone HM7) Purified (left) or Mouse IgG2a, κ Purified isotype control (right) followed by PE anti-mouse IgG. Cells were then stained with CD19 PerCP/Cyanine5.5.
Cat # Size Price Quantity Avail. Save
398102 100 µg £188
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Description

The human FCMR (also known as FcμR, FAIM, TOSO) is a type 1 transmembrane glycoprotein that belonging to the immunoglobulin (Ig) gene superfamily. FCMR had a molecular weight of ~60 kD. Human FCMR is predominantly expressed by B, T, and NK cells, but not by monocytes, granulocytes, erythrocytes, and platelets. FCMR may play roles in regulating humoral immune responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
BW5147 cells expressing human FCMR protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Application Notes

It was reported that HM7 antibody can block binding of human IgM to FCMR.

Application References

(PubMed link indicates BioLegend citation)
  1. Kubagawa H, et al. 2009. J Exp Med. 206(12): 2779-93.
  2. Kubagawa H, et al. 2014. Monoclon Antib Immunodiagn Immunother. 33(6): 393– 400.
RRID
AB_2814380 (BioLegend Cat. No. 398102)

Antigen Details

Structure
~60 kD transmembranesialoglycoprotein extracellular Ig-like domain
Distribution

B and T lymphocytes, natural killer (NK) cells, chronic lymphocytic leukemia cells, some lymphoid leukemia or lymphoma cell lines

Function
Regulates both the cell surface expression and the function of BCR, regulates humoral immune responses
Ligand/Receptor
IgM Fc
Antigen References
  1. Kubagawa H, et al. 2009. J Exp Med. 206(12): 2779-93.
  2. Shima H, et al. 2010. Int Immunol. 22(3): 149-56.
  3. Kubagawa H, et al. 2019. Front Immunol. 10:945.
  4. Meryk A, et al. 2019. Cell Rep. 26(10): 2681-91.
  5. Liu J, et al. 2019. Front Immunol. 10:529.
Gene ID
9214 View all products for this Gene ID
UniProt
View information about Fc muR on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 08/12/2019

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