- 22-19-12 (See other available formats)
- Regulatory Status
- Other Names
- SRPSOX, CXCXLG16, SR-PSOX
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
|Cat #||Size||Price||Quantity Check Availability||Save|
CXCL16, a 27 kD chemokine, exists in membrane-bound and soluble forms. Unlike classic chemokines, CXCL16 possesses a mucin-like stalk, a transmembrane domain, and a cytoplasmic tail with a tyrosine phosphorylation domain, allowing it to be expressed on the cell surface. Structurally, it is similar to fractalkine. It is expressed by dendritic cells, monocytes, and T cells. T cells can also migrate in response to CXCL16.
CXCL16 can also act as a scavenger receptor on macrophages. Its receptor is CXCR6/Bonzo. It can bind oxidized LDL and thus may play an important role in atherosclerosis. Recent studies have shown a role for CXCL16 in kidney fibrosis and in autoimmunity. CXCL16 is also a co-receptor for HIV.
- Antibody Type
- Host Species
- Purified human SR-PSOX-Fc fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats of this clone) include: in vitro blocking of chemotactic activity of CXCR6 expressing cells1. Clone 22-19-12 recognizes the chemokine domain of CXCL16 and has been shown to inhibit chemotactic activity to CXCR6-expressing cells by soluble CXCL16.1
(PubMed link indicates BioLegend citation)
- Shimaoka T, et al. 2003. J. Immunol. 171:1647. (FC, Block)
- Product Citations
AB_2562794 (BioLegend Cat. No. 360802)
- ~27 kD, exists as a membrane bound and soluble forms
- Produced by dendritic cells and T cells
- Binds to oxidized LDL and may play an important role in atherosclerosis
- Interacts with CXCR6/Bonzo
- Cell Type
- Dendritic cells, T cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Antigen References
1. Matloubian M, et al. 2000. Nat. Immunol. 1:298.
2. Wilbanks A, et al. 2001. J. Immunol. 166:5145.
3. Shimaoka T, et al. 2003. J. Immuniol. 171:1647.
4. Chandrasekar B, et al. 2004. J. Biol. Chem. 179:3188.
5. Shimaoka T, et al. 2004. J. Leukoc. Biol. 75:267.
- Gene ID
- 58191 View all products for this Gene ID
- View information about CXCL16 on UniProt.org
|PE anti-human CXCL16||22-19-12||FC|
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.