Purified anti-human CXCL16 Antibody

Pricing & Availability
22-19-12 (See other available formats)
Regulatory Status
Other Names
Mouse IgG1, κ
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Product Citations
Peripheral blood monocytes were stained with purified anti-human CXCL16 (clone 22-19-12, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
  • 22-19-12_Purified_CXCL16_Antibody_FC_111213
    Peripheral blood monocytes were stained with purified anti-human CXCL16 (clone 22-19-12, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
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360802 100 µg £157
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CXCL16, a 27 kD chemokine, exists in membrane-bound and soluble forms.  Unlike classic chemokines, CXCL16 possesses a mucin-like stalk, a transmembrane domain, and a cytoplasmic tail with a tyrosine phosphorylation domain, allowing it to be expressed on the cell surface.  Structurally, it is similar to fractalkine.  It is expressed by dendritic cells, monocytes, and T cells.  T cells can also migrate in response to CXCL16.

CXCL16 can also act as a scavenger receptor on macrophages. Its receptor is CXCR6/Bonzo.  It can bind oxidized LDL and thus may play an important role in atherosclerosis.  Recent studies have shown a role for CXCL16 in kidney fibrosis and in autoimmunity.  CXCL16 is also a co-receptor for HIV.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Purified human SR-PSOX-Fc fusion protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats of this clone) include: in vitro blocking of chemotactic activity of CXCR6 expressing cells1. Clone 22-19-12 recognizes the chemokine domain of CXCL16 and has been shown to inhibit chemotactic activity to CXCR6-expressing cells by soluble CXCL16.1

Application References

(PubMed link indicates BioLegend citation)
  1. Shimaoka T, et al. 2003. J. Immunol. 171:1647. (FC, Block)
AB_2562794 (BioLegend Cat. No. 360802)

Antigen Details

~27 kD, exists as a membrane bound and soluble forms
Produced by dendritic cells and T cells
Binds to oxidized LDL and may play an important role in atherosclerosis
Interacts with CXCR6/Bonzo
Cell Type
Dendritic cells, T cells
Biology Area
Immunology, Innate Immunity
Molecular Family
Antigen References

1. Matloubian M, et al. 2000. Nat. Immunol. 1:298.
2. Wilbanks A, et al. 2001. J. Immunol. 166:5145.
3. Shimaoka T, et al. 2003. J. Immuniol. 171:1647.
4. Chandrasekar B, et al. 2004. J. Biol. Chem. 179:3188.
5. Shimaoka T, et al. 2004. J. Leukoc. Biol. 75:267.

Gene ID
58191 View all products for this Gene ID
View information about CXCL16 on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 08/21/2014

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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  • Purified anti-human CXCL16

  • PE anti-human CXCL16


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