Purified anti-human CD7 Antibody

Pricing & Availability
Clone
4H9/CD7 (See other available formats)
Other Names
gp40
Isotype
Mouse IgG2a, κ
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Product Citations
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4H9-CD7_PURE_CD7_Antibody_093019
Human peripheral blood lymphocytes stained with CD4 APC and purified CD7 (clone 4H9/CD7) (left), or mouse IgG2a, κ isotype control (right), followed by anti-mouse IgG2a PE.
  • 4H9-CD7_PURE_CD7_Antibody_093019
    Human peripheral blood lymphocytes stained with CD4 APC and purified CD7 (clone 4H9/CD7) (left), or mouse IgG2a, κ isotype control (right), followed by anti-mouse IgG2a PE.
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395602 100 µg £64
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Description

CD7 is a 40 kD type I transmembrane glycoprotein also known as gp40. It is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL) and some acute myeloid leukemia (AML) cells. CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 costimulation can induce cytokine secretion and modulate cellular adhesion.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
T-ALL blast cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
Ig superfamily, type I transmembrane glycoprotein, 40 kD
Distribution

T cells, NK cells, thymocytes, hematopoietic progenitors, myeloid leukemic cell subsets

Function
T cell activation
Ligand/Receptor
Cytoplasmic domain associates with P13-kinase
Cell Type
Hematopoietic stem and progenitors, Leukemia, NK cells, T cells, Thymocytes
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Barclay N, et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego.
  2. Stillwell R, Bierer BE. 2001. Immunol. Res. 24:31-52. 
  3. Rabinowich H, et al. 1994. J. Immunol. 152:517-26. 
Gene ID
924 View all products for this Gene ID
UniProt
View information about CD7 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09/30/2019

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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