- S17009F (See other available formats)
- Other Names
- Interleukin 10 receptor subunit beta, CRFB4, CRF2-4, D21S58, D21S66, CDW210B
- Mouse IgG2a, κ
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- Product Citations
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CD210b is a Type 1 transmembrane glycoprotein also known as, subunit 2 (IL-10R2) and is an essential chain for the IL-10 receptor complex. The IL-10 receptor complex is made up of alpha (IL10-RA) and beta (IL-10RB) subunits. Coexpression of these subunits has been shown to be required for IL10 induced signal transduction. Binding of dimeric IL-10 to two alpha subunits can cause the recruitment of two beta subunits resulting in the transduction of the intracellular JAK/STAT pathway.Product Details
- Antibody Type
- Host Species
- Human IL10RB-transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Type 1 transmembrane glycoprotein belonging to the cytokine receptor family.
CD210b is expressed by a variety of cell types including T cells, B cells, NK cells, monocytes and macrophages.
- Activates STAT1, STAT3, Jak1, Tyk and is a component of cytokine receptor complexes specific for IL-22, IL-26, IL-28, and IL-29.
- Cell Type
- B cells, Macrophages, NK cells, T cells, Thymocytes
- Biology Area
- Adaptive Immunity, Immunology, Signal Transduction
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
- Donnelly RP, et al. 2004. J Leukoc Biol. 76(2):314-321.
- Koppelman B, et al. 1997. Immunity. (6): 861-871
- Kotenko SV, et al. 1997. EMBO J. 16(19):5894-5903.
- Liu Y, et al. 1995. J Immunol. 152(4):1821-1829.
- Gene ID
- 3588 View all products for this Gene ID
- View information about CD210b on UniProt.org
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