Purified anti-human CD200 (OX2) Antibody

Pricing & Availability
Clone
A18042B (See other available formats)
Other Names
OX-2, OX2
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
A18042_PURE_CD200_Antibody_050820
Human peripheral blood lymphocytes were stained with purified anti-human CD200 (OX2) (clone A18042B) (left) or mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE. Cells were Co-stained with CD4 APC.
  • A18042_PURE_CD200_Antibody_050820
    Human peripheral blood lymphocytes were stained with purified anti-human CD200 (OX2) (clone A18042B) (left) or mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE. Cells were Co-stained with CD4 APC.
Cat # Size Price Quantity Avail. Save
399802 100 µg £68
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Description

CD200, also known as OX2, is a member of the immunoglobulin superfamily (IgSF). It is a monomorphic cell surface glycoprotein that is expressed on thymocytes, neurons, endothelium, follicular dendritic cells in all lymphoid organs, a subset of CD34+ progenitor cells, and at low levels on some smooth muscle and B lymphocytes. It is not expressed on NK cells, monocytes, granulocytes, or platelets. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. The interaction between CD200 (OX2) and CD200 receptor (OX2R) system is of importance in the control of macrophage and granulocyte activation, which may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human CD200
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone A18042B antibody is able to completely block the staining of OX-104 antibody, but OX-104 antibody does not completely block the staining of A18042B antibody.

RRID
AB_2861014 (BioLegend Cat. No. 399802)

Antigen Details

Structure
Ig superfamily, 80 kD
Distribution

T cells, neurons, endothelium

Function
Costimulates T cell proliferation
Ligand/Receptor
CD200R
Cell Type
Endothelial cells, Neurons, T cells
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules
Antigen References
  1. Wright GJ, et al. 2001. Immunology. 102:173.
  2. Foster-Cuevas M, et al. 2004. J. Virol. 78:7667.
  3. Mason D, et al. 2002. ed. Leukocyte Typing VII. New York:Oxford Univ. Press.
  4. Broderick C, et al. 2002. Am. J. Pathol. 161:1669.
Gene ID
4345 View all products for this Gene ID
UniProt
View information about CD200 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 04/23/2020

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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