Purified anti-human CD196 (CCR6) Recombinant Antibody

Pricing & Availability
Clone
QA17A37 (See other available formats)
Other Names
BN-1, CKR6, DCR2, CKRL3, DRY-6, GPR29, CKR-L3, CMKBR6, GPRCY4, STRL22, GPR-CY4
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publications
QA17A37_PURE_CD196_Antibody_032221
Human peripheral lymphocytes were stained with CD19 APC and purified CD196 (CCR6) recombinant (clone QA17A37 (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
  • QA17A37_PURE_CD196_Antibody_032221
    Human peripheral lymphocytes were stained with CD19 APC and purified CD196 (CCR6) recombinant (clone QA17A37 (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
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399002 100 µg £133
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Description

CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

 

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This recombinant antibody clone is derived from clone G034E3.

Antigen Details

Structure
Chemokine receptor, GPCR, seven transmembrane receptor
Distribution

Immature dendritic cells, B lymphocytes, memory T cells, Th17 cells

Function
Host defense, important for recruitment of B cells to secondary lymphoid organs, mediates arrest of T cells on dermal endothelial cells
Ligand/Receptor
CCL20 (MIP-3α)
Antigen References

1. Zaballos A, et al. 1996. Biochem. Bioph. Res. Co. 227:846.
 2. Yang D, et al. 1999. Science 286:525.
 3. MacDonald KG, et al. 2007. Am. J. Pathol. 170:1229.
 4. Homey B, et al. 2000. J. Immunol. 164:6621.
 5. Hirota K, et al. 2007. J. Exp. Med. 204:2803.
 6. Singh SP, et al. 2008. J. Immunol. 180:214.

Gene ID
1235 View all products for this Gene ID
UniProt
View information about CD196 on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 03/22/2021

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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