- RM3/1 (See other available formats)
- Regulatory Status
- Other Names
- GHI/61, M130, RM3/1, p155, Hemoglobin/haptoglobin complex receptor, Macrophage-associated antigen, ED2(rat), Macrophage marker
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kuffer cells, monocytes, subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammation diseases.Product Details
- Antibody Type
- Host Species
- Human monocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
ICC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone RM3/1 binds to domain 9 of CD163. Additional reported applications (for the relevant formats) include: immunofluorescence7.
(PubMed link indicates BioLegend citation)
- Högger P, et al. 1998. J. Immunol. 161:1883. (FC)
- Zwadlo G, et al. 1987. Exp. Cell Biol. 55:295. (FC)
- Buechler C, et al. 2000. J. Leukoc. Biol. 67:97. (FC)
- Puig-Kroger A, et al. 2009. Cancer Res. 69:9395. (FC) PubMed
- Madsen M, et al. 2004. J. Biol. Chem. 279:51561. (FC)
- Jones K, et al. 2013. Clin Cancer Res. 19:731. (FC) PubMed
- Stewart DA, et al. 2012. Mol. Cancer Res. 10:727. (IF)
- Product Citations
AB_893267 (BioLegend Cat. No. 326502)
- 134 kD (non-reduced)/155 kD (reduced) glycoprotein, Scavenger receptor superfamily
Monocytes, macrophages, Kuffer cells, subset of dendritic cells, subset of hematopoietic stem/progenitor cells
- Clearance of haptoglobin-hemoglobin complex, regulation of cytokine production by macrophages
- Haptoglobin-hemoglobin complex, TWEAK
- Cell Type
- Dendritic cells, Hematopoietic stem and progenitors, Macrophages, Monocytes
- Biology Area
- Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules
- Antigen References
1. Roth J, et al. 1994. Transolantation. 57:127.
2. Van den Heuvel MM, et al.1999. J. Leukoc. Biol. 66:858.
3. Sulahian TH, et al. 2000. Cytokines 12:1312.
4. Fabriek BO, et al. 2007. J. Neuroimmunol. 187:179.
- Gene ID
- 9332 View all products for this Gene ID
- View information about CD163 on UniProt.org
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