- QA18A13 (See other available formats)
- Regulatory Status
- Other Names
- FcγRIII, Fc gamma receptor, Fc gamma receptor 3
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2892392 (BioLegend Cat. No. 325902)
- Ig superfamily, transmembrane form (50-65 kD) or GPI-linked form (48 kD)
- Low affinity IgG Fc receptor, phagocytosis, ADCC
- Aggregated IgG, IgG-antigen complex
- Antigen References
- Rataj, et al. 2019. Br J Cancer. 120:79-87.
- Gene ID
- 2214 View all products for this Gene ID
- View information about CD16 on UniProt.org
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