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- Clone
- HP-DM1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- NKAT, NKAT1, p58.1, CD158A, KIR221, NKAT-1, KIR-K64
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Human peripheral blood lymphocytes were stained with purified CD158a (KIR2DL1) (clone HP-DM1) (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD56 APC.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 374902 | 100 µg | £77 | ||||
CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and posses inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 15 polymorphic KIR genes have been reported in humans. CD158a is an inhibitory receptor and is mainly expressed on a subset of NK cells and a small population of CD8+ T cells. HP-DM1 is reported to specifically recognizes CD158a.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human NK Cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) - RRID
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AB_2890805 (BioLegend Cat. No. 374902)
Antigen Details
- Structure
- Contains two Ig-like extracellular domains
- Distribution
-
NK cells and a small subset of T cells
- Function
- Inhibits NK cell function
- Interaction
- NK cells, T cells
- Ligand/Receptor
- HLA-C
- Cell Type
- Lymphocytes, NK cells, NKT cells, T cells
- Biology Area
- Immunology
- Antigen References
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- Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
- Gene ID
- 3802 View all products for this Gene ID
- UniProt
- View information about CD158a on UniProt.org
Related FAQs
Other Formats
View All CD158a Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-human CD158a (KIR2DL1) | HP-DM1 | FC |
| Purified anti-human CD158a (KIR2DL1) | HP-DM1 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PE anti-human CD158a (KIR2DL1)
Human peripheral blood lymphocytes were stained with CD56 AP... -
Purified anti-human CD158a (KIR2DL1)
Human peripheral blood lymphocytes were stained with purifie...
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