Purified anti-HSPA1L Antibody

Pricing & Availability
Clone
BL28548 (See other available formats)
Other Names
HSPA1L, Heat shotck 70 kDa protein 1-like
Isotype
Mouse IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
BL28548_Purified_HSPA1L_Antibody_1_111918.png
Western blot of purified anti-HSPA1L antibody (clone BL28548). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • BL28548_Purified_HSPA1L_Antibody_1_111918.png
    Western blot of purified anti-HSPA1L antibody (clone BL28548). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
Cat # Size Price Quantity Avail. Save
Coming Soon 25 µg £60  
Description

HSPA1L is a chaperone protein belonging to the heat shock protein 70 (HSP70) family. HSPA1L participates in multiple biological processes, such as apoptosis, cell growth and differentiation, by facilitating the folding of newly-translated proteins and the degradation of misfolded proteins. Overexpression of HSPA1L mitigates symptoms of neurodegenerative diseases including Alzheimer’s Diseases, and Parkinson’s diseases, suggesting that HSPA1L has the potential to serve as a diagnostic/prognostic biomarker for these disorders.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2783439 (BioLegend Cat. No. 854801)

Antigen Details

Structure
HSPA1L is a 641 amino acid protein with an apparent molecular mass of ~ 70 kD.
Distribution

Tissue Distribution: Highly expressed in testis. Ubiquitously expressed in low level in all tissues.
Cellular Distribution: Cytosol, extracellular, and nucleus

Function
HSPA1L is a chaperone protein that facilitates folding of newly synthesized proteins as well as degradation of misfolded proteins.
Interaction
Known to interact with PRKN and HIF-1alpha
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Antigen References
  1. Huusko JM, et al. 2018. PLoS Genet. 14(7):e1007394
  2. Lee JH, et al. 2017. Oncogene. 36(47):6555
  3. Takahashi S, et al. 2017, Genome Med. 9(1):8
Gene ID
3305 View all products for this Gene ID 15482 View all products for this Gene ID 24963 View all products for this Gene ID
UniProt
View information about HSPA1L on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/20/2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 9727 Pacific Heights Blvd, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Login / Register
Forgot your password? Reset password?
Create an Account