- BL28632 (See other available formats)
- Other Names
- Haptoglobin-Related Protein, Haptoglobin-Related Locus, A-259H10.2
- Mouse IgG2b, κ
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- Product Citations
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Haptoglobin-Related Protein (HPR) is a primate-specific plasma protein that binds to hemoglobin as efficiently as haptoglobin. HPR is also involved in human innate immune protection through its association with high-density lipoprotein (HDL). It may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron. HPR is associated with diseases including anhaptoglobinemia and sleeping sickness, and may serve as an important predictor of recurrence of breast cancer.Product Details
- Antibody Type
- Host Species
- Recombinant HPR expressed in E.coli.
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- HPR is a 348 amino acid protein with an apparent molecular mass of ~ 39 kD.
Tissue Distribution: Liver and kidney
Cellular Distribution: Cytosol
- HPR is involved in the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
- Cell Type
- Mesenchymal cells
- Biology Area
- Cancer Biomarkers, Immuno-Oncology, Immunology, Innate Immunity
- Molecular Family
- Carrier Proteins, Innate Immune Signaling
- Antigen References
- Nielsen MJ, et al. 2009. Blood. 114(4):764.
- Martin-Lorenzo M, et al. 2019. Hypertension. 73(4):794.
- Gene ID
- 3250 View all products for this Gene ID
- View information about HPR on UniProt.org
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