- W17230A (See other available formats)
- Other Names
- Growth Factor Receptor Bound Protein 2, SH2/SH3 Adaptor Protein GRB2, ASH, Epidermal Growth Factor Receptor-Binding Protein GRB2, Abundant SRC Homology, MSTP084, Grb3-3, MST084, NCKAP2
- Rat IgG2a, κ
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- Product Citations
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GRB2 is a receptor tyrosine kinase (RTK) adaptor protein that transduces signaling cascades from activated receptors. Upon receptor stimulation, GRB2 binds phosphorylated RTK tyrosine residues via a central SH2 domain; flanking GRB2 SH3 domains facilitate the recruitment of downstream effectors to the activated RTK.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Synthetic peptide corresponding to amino acid residues 199-214 of human GRB2.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone has not been tested for ICC or IP.
- GRB2 is a 217 amino acid protein with a predicted molecular weight of 25 kD.
Plasma membrane-associated/ubiquitously expressed
- Adaptor protein in RTK signaling pathways
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Adaptor Proteins, Phospho-Proteins
- Antigen References
- Lowenstein EJ, et al. 1992. Cell. 70:431-42.
- Matuoka K, et al. 1992. Proc Natl Acad Sci U S A. 89:9015-9.
- Skolnik EY, et al. 1993. Science. 260:1953-5.
- Pendergast AM, et al. 1993. Cell. 75:175-85.
- Gene ID
- 2885 View all products for this Gene ID
- View information about GRB2 on UniProt.org
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