- O93A6 (See other available formats)
- Other Names
- GPHN, Gephyrin
- Mouse IgG2a, κ
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- Product Citations
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Gephyrin (GPHN) is a scaffold protein that anchors glycine and GABA receptors to the tubulin cytoskeleton in the postsynaptic terminal of inhibitory synapses. Gephyrin's function as a scaffolding protein is regulated at transcriptional and translational levels, which impact the formation and plasticity of GABAergic synapses, as well as the overall strength of GABAergic transmission. Low levels of gephyrin in temporal lobe correspond to reduced inhibitory signals and correlate with temporal lobe epilepsy.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Human recombinant gephyrin expressed in human HEK293T cells.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2783450 (BioLegend Cat. No. 856101)
AB_2783451 (BioLegend Cat. No. 856102)
- Gephyrin is a 736 amino acid protein with an apparent molecular mass of ~ 93 kD.
Tissue Distribution: Nervous system, endocrine system, and gastrointestinal tract.
Cellular Distribution: Plasma membrane, cytoskeleton, and cytosol.
- Gephyrin is a scaffolding protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton.
- Homodimer and homo-oligomer, interacts with GLRB, GABARAP, GABRA3, GLRB.
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Postsynaptic proteins
- Antigen References
- Alvarez FJ. 2017. Brain Res. Bull. 129:50.
- Tyagarajan SK, Fritschy JM. 2014. Nat. Rev. Neurosci. 15:141-56.
- Zacchi P, et al. 2014. Front Cell. Neurosci. 8:103.
- Gene ID
- 10243 View all products for this Gene ID 268566 View all products for this Gene ID 64845 View all products for this Gene ID
- View information about Gephyrin on UniProt.org
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