- 12H12 (See other available formats)
- Other Names
- Mouse IgG1, κ
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Gemin 3, also known as DEAD-box helicase 20 (DDX20), is a putative RNA helicase that contains a conserved ASP-GLU-ALA-ASP (DEAD) motif. Gemin 3 is involved in a variety of cellular processes including initiation of protein translation, ribosome assembly, and alteration of RNA secondary structure. Gemin 3 is one of the core components of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. Gemin 3 may also be involved in cancer as it acts as a tumor suppressor in hepatocellular carcinoma, and as a tumor promoter in breast cancer and prostate cancer2.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Gemin 3 is an 824 amino acid protein with an apparent molecular mass of ~ 92 kD.
Tissue Distribution: Testis and ovary
Cellular Distribution: Cytosol, nucleus, and cytoskeleton
- Gemin 3 is a component of SMN macromolecule protein complex.
- SMN, GEMIN4
- Cell Type
- Astrocytes, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes
- Biology Area
- Cancer Biomarkers, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors
- Antigen References
- Seng CO, et al. 2015. Hum. Mol. Genet. 24(8):2138.
- Chen W, et al. 2016. Int. J. Mol. Med. 37(6):1551.
- Gene ID
- 11218 View all products for this Gene ID
- View information about Gemin 3 on UniProt.org
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