- BL28631 (See other available formats)
- Other Names
- Elastin, Tropoelastin, ADCL1, SVAS, WBS
- Mouse IgG1, κ
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- Product Citations
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Elastin is a protein that composes elastic fibers in extracellular matrix to confer elasticity of organs including skin, lung, and colon. Elastokines, which are fragments degraded from elastin, stimulate proliferation and migration of skin fibroblasts and monocytes, through ERK and integrin signaling pathways. Elastins are involved in cancer progression and diseases including supravalvular aortic stenosis and cutis laxa.Product Details
- Antibody Type
- Host Species
- Recombinant Elastin expressed in E.coli.
- 0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage, aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 5.0 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Elastin is a 786 amino acid protein with an apparent molecular mass of ~68 kD.
Tissue Distribution: Heart, kidney, lung, skin
Cellular Distribution: Extracelluar, membrane
- Elastin is involved in skin fibroblast migration and proliferation, and cancer progression.
- MFAP2, FBN1, FBLN2, FBLN5 and MFAP4
- Cell Type
- Endothelial cells, Mesenchymal Stem Cells
- Biology Area
- Cardiovascular Biology, Cell Biology, Signal Transduction
- Molecular Family
- Adhesion Molecules
- Antigen References
- Weihermann AC, et al. 2017. Int J Cosmet Sci. 39(3):241-247.
- Wahart A, et al. 2019. FEBS J. 286(15):2980-2993.
- Gene ID
- 2006 View all products for this Gene ID
- View information about Elastin on UniProt.org
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