- 3D5-C6-D5 (See other available formats)
- Other Names
- DCTN1, Dynactin Subunit 1
- Mouse IgG2b, κ
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- Product Citations
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Dynactin 1 is the largest subunit of the macromolecular complex dynactin, which is essential for dynein-mediated retrograde transport of vesicles and organelles. Dynactin 1 is clinically identified as a causative gene for Perry syndrome (PS), which is a neurodegenerative disease characterized by autosomal dominant inheritance, parkinsonism, and central hypoventilation. Mutations in dynactin 1 are also associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.Product Details
- Antibody Type
- Host Species
- Purified recombinant Dynactin 1 protein fragments expressed in E.coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Dynactin 1 is a 1278 amino acid protein with two reported isoforms. A brain-specific isoform with predicted and observed molecular mass of ~135 kD, and a ubiquitously expressed isoform with predicted and observed molecular mass of ~150 kD.
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Cytoskeleton, cytosol, and nucleus
- Dynactin 1 recruits dynein to microtubules and facilitates retrograde transport of vesicles and organelles.
- Dynactin 1 forms homodimer and interacts with dynein.
- Biology Area
- Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance, Synaptic Biology
- Molecular Family
- Adaptor Proteins, Carrier Proteins, Cytoskeletal Proteins, Neurotransmitter Receptor Trafficking/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
- Konno T, et al. 2017. Parkinsonism Relat Disord. 41:14.
- Houlden H, et al. 2012. Acta Neuropath. 124(3):325.
- Tanaka F, et al. 2011. Rinsho Shinkeigaku. 51(11):1189.
- Gene ID
- 1639 View all products for this Gene ID
- View information about Dynactin 1 on UniProt.org
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