- O94A3 (See other available formats)
- Mouse IgG1, κ
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Doublecortin (DCX) is a microtubule-associated protein that is predominantly expressed in embryonic brains by neuronal precursor cells or immature neurons. DCX is also expressed in the adult brains in regions such as subventricular zones and dentate gyrus, where neuronal precursor cells are localized, and thus has been widely used as a marker for neurogenesis. Doublecortin binds to the microtubule cytoskeleton and stabilizes microtubule bundles. Mutation in DCX has been identified in diseases such as X-linked lissencephaly and double cortex syndrome.Product Details
- Antibody Type
- Host Species
- Full-length human recombinant DCX protein produced in HEK293T cell.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- DCX is a 366 amino acid protein with predicted and observed molecular mass of ~41 kD
Tissue Distribution: Brain
Cellular Distribution: Cytoskeleton, cytosol, and nucleus
- DXC is a markers for neurogenesis. It binds to the microtubule cytoskeleton and stabilizes microtubule bundles.
- Tubulin, USP9X
- Cell Type
- Neural Stem Cells, Neurons
- Biology Area
- Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability, Cell Structure, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Cytoskeletal Proteins, Microtubules
- Antigen References
- Ayanlaja AA, et al. 2017. Front Mol Neurosci. 10:199
- Reiner O. 2013. Scientifica (Cairo). 2013:393975
- Reiner O, et al. 2004. Cell Cycle. 3(6):747
- Gene ID
- 13193 View all products for this Gene ID
- View information about Doublecortin on UniProt.org
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