- W17239A (See other available formats)
- Other Names
- Peptidylprolyl Isomerase F, Peptidyl-Prolyl Cis-Trans Isomerase F, Mitochondrial, Mitochondrial Cyclophilin, Cyclophilin F, Rotamase F, PPIase F, CyP-M, CYP3, CypD, Cyclophilin 3, Cyp-D, CyP-D, PPIF
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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Cyclophilin D is one of the three components of the permeability transition pore (PTP) localized in the mitochondrial matrix. The opening of the PTP is a key event in the initiation of cell death which leads to mitochondrial swelling, outer membrane rupture, and the release of apoptotic regulators such as cytochrome C. Cyclophilin D promotes mitochondrial permeability transition (mPT) in response to increased Ca2+ level. Cyclophilin D deficient mice have shown desensitization to mTP and require twice as much Ca2+ intake for the opening of the PTP compared to wild-type mice.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Partial recombinant human PPIF protein (30-207 a.a.)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone recognizes human cyclophilin D
This clone failed IP testing
AB_2814520 (BioLegend Cat. No. 670001)
AB_2814521 (BioLegend Cat. No. 670002)
- Cyclophilin D is a 207 amino acid protein with a predicted molecular weight of 22 kD
Mitochondrial matrix/Ubiquitously expressed
- Apoptotic regulator
- Biology Area
- Cell Death, Mitochondrial Function
- Molecular Family
- Mitochondrial Markers
- Antigen References
- Baines C, et al. 2005. Nature. 434:658
- Schinzel A, et al. 2005. PNAS. 102:12005
- Basso E, et al. 2005. J BioL Chem. 280:18558
- Gene ID
- 10105 View all products for this Gene ID
- View information about Cyclophilin D on UniProt.org
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