- P1E11 (See other available formats)
- Regulatory Status
- Other Names
- GJA1, Cx43, Gap Junction Protein Alpha 1
- Mouse IgG1, κ
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- Product Citations
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Connexins are a family of transmembrane proteins that assemble to form vertebrate gap junctions, thus also called Gap Junction Proteins. So far, 21 Connexins have been discovered in humans. The gene GJA1 encodes Connexin 43 (Cx43), which is the most expressed Connexin, and can be found in many human tissues including skin, bone, and brain. Cx43 has been reported to be involved in synchronized contraction of the heart as well as embryonic development. Besides its functions as a channel protein, Cx43 also performs channel-independent functions. During brain and heart development, cytoplasmic Cx43 regulates the microtubule network and thus affects cell migration and polarity. In addition, mitochondrial GJA1 has also been reported to promote cell survival by down-regulating the intrinsic apoptotic pathway during conditions such as oxidative stress.Product Details
- Mouse, Rat
- Antibody Type
- Host Species
- A peptide corresponding to amino acids 1-20 of Connexin 43
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 to 5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Pollmann MA, et al. 2005. Breast Cancer Res. 7(4):R522 (WB)
- Kozoriz MG, et al. 2010. J Neuropathol Exp Neurol. 69(2): 196 (WB)
- Maass K, et al. 2007. Circ Res. 101(12):1283 (WB)
- Gellhaus A, et al. 2010. J Cell Biochem. 110(1):129 (WB)
- Oxford EM, et al. 2007 Circ Res. 101(7): 703 (WB)
AB_2715866 (BioLegend Cat. No. 849901)
AB_2715867 (BioLegend Cat. No. 849902)
- Connexin 43 (GJA1) is a 382 amino acid protein with a molecular mass of 43 kD.
Tissue distribution: expressed in most tissues, enriched in brain, endocrine, muscle, bone marrow, immune system, ovaries, testes, heart and skin.
Cellular distribution: plasma membrane, cytosol, mitochondria, golgi apparatus, cytoskeleton and endoplasmic reticulum membrane.
- Connexin 43 plays a role in cell-to-cell communication by forming channels, or gap junctions between cells. It allows for the transport of nutrients, charged particles (ions), and other small molecules that carry necessary communication signals between cells.
- Biology Area
- Cell Adhesion, Cell Biology
- Molecular Family
- Gap Junction Proteins
- Antigen References
1. Grek CL, et al. 2016. Cancer Lett. 374(1):117
2. Lilly E, et al. 2016. Semin Cell Dev Biol. 50:4
3. Michela P, et al. 2015. Eur J Pharmacol. 768:71
- Gene ID
- 2697 View all products for this Gene ID
- View information about Connexin 43 1-20 on UniProt.org
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