Purified anti-CCL11 (Eotaxin) Antibody

Pricing & Availability
Clone
L402H11 (See other available formats)
Regulatory Status
RUO
Other Names
Chemokine (C-C Motif) ligand 11, Eotaxin-1, Eosinophil chemotactic protein, Small-inducible cytokine A11
Isotype
Rat IgG2a
Ave. Rating
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Product Citations
publications
L402H11_Purified_CCL11_Antibody_WB_043014
Western blot analysis of 50 ng of recombinant human CCL11 (lane 1) and 50 ng of recombinant mouse CCL11 (lane 2) using anti-mouse CCL11 antibody (clone L402H11).
  • L402H11_Purified_CCL11_Antibody_WB_043014
    Western blot analysis of 50 ng of recombinant human CCL11 (lane 1) and 50 ng of recombinant mouse CCL11 (lane 2) using anti-mouse CCL11 antibody (clone L402H11).
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660402 100 µg £147.00
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Description

CCL11 selectively recruits eosinophils through binding to the chemokine receptor CCR3 during allergic response. CCL11 production is upregulated in response to several proimflammatory cytokines, such as IL-4, IL-13, TNF-α, and IFN-α, produced by mast cells and Th2 lymphocytes. CCL11 has been reported to stimulate eosinophil release from bone marrow, resulting in an elevated level of circulating eosinophils.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human CCL11 recombinant protein (Gly24-Pro97) expressed in E. coli.
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
Affinity purified.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2563471 (BioLegend Cat. No. 660402)

Antigen Details

Structure
74 amino acid, predicted molecular weight of approximately 12 kD.
Distribution

Secreted. Epithelial cells, smooth muscle cells, dendritic cells, and fibroblasts.

Interaction
Eosinophils
Ligand/Receptor
CCR3
Cell Type
Epithelial cells, Dendritic cells, Fibroblasts, Eosinophils
Biology Area
Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Conroy DM, et al. 2001. Respir. Res. 2:150.
2. Levina V, et al. 2009. Clin. Cancer Res. 15:2647.
3. Salcedo R, et al. 2001. J. Immunol. 166:7571.
4. Kaehler J, et al. 2006. J. Investig. Med. 54:446.
5. Hadjicharalambous C, et al. 2004. J. Allergy Clin. Immunol. 113:657.
6. Crump MP, et al. 1998. J. Biol. Chem. 273:22471.

Gene ID
6356 View all products for this Gene ID
UniProt
View information about CCL11 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 09/26/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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