- W17221A (See other available formats)
- Other Names
- Baculoviral IAP Repeat Containing 3, Inhibitor Of Apoptosis Protein 1, Apoptosis Inhibitor 2, TNFR2-TRAF-Signaling Complex Protein 1, RNF49, MIHC, API2
- Rat IgG2a, κ
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- Product Citations
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Baculoviral IAP Repeat Containing Protein 3, or BIRC3, is a member of the Inhibitor of apoptosis (IAP) family of proteins initially characterized as a component of the TNFα receptor signaling complex. BIRC3 functions as an E3 ubiquitin ligase, polyubiqiutinating target proteins such as RIP kinases, caspases, TRAF1, and BCL10. Loss of BIRC3 results in a significant impairment of TNFα-mediated NF-κB activation signaling cascades.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Partial recombinant protein corresponding to amino acids 355-604 of human BIRC
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Application Notes
This clone has not been tested for IP.
This clone failed to test 4% PFA-fixed Ramos cells permabilized with either methanol or Triton X-100; we do not recommend using the clone for ICC.
This clone produced additional bands between ~65 and 95 kD when tested by WB. These bands were also observed with a control antibody raised with a separate epitope. These bands may represent ubiquitinated BIRC3.
- BIRC3 is a 604 amino acid protein with a predicted molecular weight of 68 kD.
Nucleus, cytoplasm/widely expressed
- Inhibits apoptosis
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Innate Immunity, Signal Transduction, Ubiquitin/Protein Degradation
- Antigen References
- Seitz CS, et al. 2000. J. Clin. Invest. 105:253.
- Contze DB, et al. 2005. Mol Cel Biol. 25:3384.
- Rahal R, et al. 2014. Nat. Med. 20:87.
- Gene ID
- 330 View all products for this Gene ID
- View information about BIRC3 on UniProt.org
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