- 8D4-D6-D11 (See other available formats)
- Other Names
- ALDH2, Aldehyde Dehydrogenase 2 Family (Mitochondrial)
- Mouse IgG1, κ
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- Product Citations
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ALDH2 is a member of the aldehyde dehydrogenase family. In the human brain, ALDH2 is the major aldehyde metabolizing enzyme that is essential for the metabolism and detoxification of endogenous and exogenous aldehyde substrates. In line with this, recent studies have reported that ALDH2 level is dysregulated in the brains of patients with Parkinson’s and Alzheimer's diseases, suggesting toxic aldehydes as a contributing factor to neurodegenerative diseases and a potential therapeutic target.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Purified recombinant human ALDH2 fragments expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- ALDH2 is a 517 amino acid protein with predicted and observed molecular mass of ~ 56 kD.
Tissue Distribution: Mainly expressed in adrenal gland, lung, kidney, and brain
Cellular Distribution: Mitochondrion and cytosol
- Aldehyde metabolizing enzyme that is essential for the metabolism and detoxification of endogenous and exogenous aldehyde substrates.
- Forms homo-tetramers
- Cell Type
- Astrocytes, Microglia, Neurons, Oligodendrocytes
- Biology Area
- Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience
- Molecular Family
- Aldehyde Dehydrogenases, Mitochondrial Markers
- Antigen References
- Chen CH, et al. 2016. Acta. Neurol. Taiwan. 25(4):111-123.
- Chauhan G, Debette S. 2016. Curr. Cardiol. Rep. 18(12):124.
- Grünblatt E, Riederer P. 2016. J. Neural Transm. (Vienna). 123(2):83-90.
- Gene ID
- 217 View all products for this Gene ID 11669 View all products for this Gene ID 29539 View all products for this Gene ID
- View information about ALDH2 on UniProt.org
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