PE/Cy7 anti-human MRGX2 Antibody

Pricing & Availability
Clone
K125H4 (See other available formats)
Other Names
Mas-related G-protein coupled receptor member X2, MRGPRX2
Isotype
Mouse IgG2b, κ
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Product Citations
publications
K125H4_PECy7_MRGX2_Antibody_081018
Human MRGX2 transfected CHO cells were stained with MRGX2 (clone K125H4) PE/Cy7 (filled histogram) or Mouse IgG2b, κ PE/Cy7 isotype control (open histogram).
  • K125H4_PECy7_MRGX2_Antibody_081018
    Human MRGX2 transfected CHO cells were stained with MRGX2 (clone K125H4) PE/Cy7 (filled histogram) or Mouse IgG2b, κ PE/Cy7 isotype control (open histogram).
See PE/Cy7 spectral data
Cat # Size Price Quantity Avail. Save
359007 25 tests £97
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359008 100 tests £235
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Description

MRGX2 (Mas-related G-protein coupled receptor member X2) is a 36 kD, seven transmembrane protein expressed on mast cells and sensory neurons from the dorsal root ganglia. MRGX2 is involved in mast cell-degranulation, and may regulate the function and development of sensory neurons. Originally described as an orphan receptor, it has been reported MRGX2 binds defensins and costistatin.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
DNA vaccine containing the full length gene of human MRGX2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2750141 (BioLegend Cat. No. 359007)
AB_2783262 (BioLegend Cat. No. 359008)

Antigen Details

Structure
Seven transmembrane domains, 36 kD, member of the GPCR family
Distribution

Mast cells, sensory neurons from the dorsal root ganglia

Function
Involved in mast cell-degranulation, may regulate function and development of sensory neurons
Interaction
Coupled to G-proteins Gαq and Gαi
Ligand Receptor
Defensins, cortistatin
Cell Type
Mast cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Subramanian H, et al. 2013. J. Immunol. 191:345.
2. Subramanian H, et al. 2011. J. Biol. Chem. 286:44739. 
3. Yang S, et al. 2005. Gene. 352:30.
4. Robas N, et al. 2003. J. Biol. Chem. 278:44400.

Gene ID
117194 View all products for this Gene ID
UniProt
View information about MRGX2 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 08/10/2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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