- S17016D (See other available formats)
- Other Names
- NKR-P1C, NKR-P1B, Ly-55, CD161b, CD161c
- Mouse IgG2a, κ
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- Product Citations
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NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.Product Details
- Antibody Type
- Host Species
- NK-1+ cells from mouse spleen and bone marrow
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Clone S17016D cross-blocks anti-mouse NK1.1 clone PK136, and can stain for NK1.1 post-formaldehyde and methanol-based fixation based on in-house testing.
AB_2783135 (BioLegend Cat. No. 156503)
AB_2783136 (BioLegend Cat. No. 156504)
- NKR-P1 gene family
NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)
- NK cell activation, IFN-γ production, cytotoxic granule release
- Cell Type
- NK cells, NKT cells
- Biology Area
- Immunology, Innate Immunity
- Antigen References
- Lanier LL. 1997. Immunity 6:371.
- Yokoyama WM, Seaman WE. 1993. Annu. Rev. Immunol. 11:613.
- Koo GC, et al. 1986. J. Immunol. 137:3742.
- Giorda R, Trucco M. 1991. J. Immunol. 147:1701.
- Gene ID
- 17059 View all products for this Gene ID
- View information about NK-1.1 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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