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PE anti-mouse IL-17RB Antibody

Pricing & Availability
Clone
9B10 (See other available formats)
Regulatory Status
RUO
Other Names
Evi27, IL-17ER, IL17RH1, IL17br, IL-17 receptor B
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
9B10_PE_IL-17RB_Antibody_FC_102714
Mouse IL-17RB transfected 300.19 cells were stained with IL-17RB (clone 9B10) PE (filled histogram) or rat IgG2a, κ PE isotype control (open histogram).
  • 9B10_PE_IL-17RB_Antibody_FC_102714
    Mouse IL-17RB transfected 300.19 cells were stained with IL-17RB (clone 9B10) PE (filled histogram) or rat IgG2a, κ PE isotype control (open histogram).
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146305 25 µg £105
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146306 100 µg £255
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Description

IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family.  IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R.  It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells.  It binds IL-17B and IL-17E (IL-25) but not IL-17A or C.  Its interaction with IL-25 has a higher affinity than that with IL-17B.  Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1.  IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse IL-17RB - Fc chimera (human IgG1)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Wiesner DL, et al. 2015. PLoS Pathog. 11:1004701. PubMed
Product Citations
  1. Wiesner D, et al. 2015. PLoS Pathog. 11:1004701. PubMed
  2. Matsubara K, et al. 2016. Hypertens Res. 10.1038/hr.2015.160. PubMed
  3. Zeis P, et al. 2020. Immunity. 53:775. PubMed
  4. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
RRID
AB_2564511 (BioLegend Cat. No. 146305)
AB_2564512 (BioLegend Cat. No. 146306)

Antigen Details

Structure
Single pass type I transmembrane protein, 55.9 kD
Distribution
iNKT cells, innate lymphoid cells, Th2 cells
Function
Binds IL-25 with higher affinity than IL-17B, can block IL-25 mediated pathology
Interaction
TRAF6 and Act1
Ligand/Receptor
IL-25/IL-17E
Cell Type
NKT cells, Th2
Biology Area
Immunology, Innate Immunity
Molecular Family
Cytokine/Chemokine Receptors
Antigen References

1. Hwang SY, et al. 2004. Arthritis Res. Ther. 6:R120.
2. Rickel EA, et al. 2008. J. Immunol. 181:4299.
3. Terashima A, et al. 2008. J. Exp. Med. 205:2727.

Gene ID
50905 View all products for this Gene ID
UniProt
View information about IL-17RB on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 10/31/2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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