PE anti-mouse DcTRAIL-R1 Antibody

Pricing & Availability
Clone
mDcR1-3 (See other available formats)
Regulatory Status
RUO
Other Names
TNFRH1, mSOB, Tumor necrosis factor receptor superfamily member 23, Tnfrsf23, Tumor necrosis factor receptor p60 homolog 1, TNF receptor family member SOB, Decoy TRAIL receptor 1, TNF receptor homolog 1
Isotype
Armenian Hamster IgG
Ave. Rating
Submit a Review
Product Citations
publications
mDcR1_PE_051409.jpg
Mouse macrophage cell line RAW stained with mDcR1-3 PE
  • mDcR1_PE_051409.jpg
    Mouse macrophage cell line RAW stained with mDcR1-3 PE
See PE spectral data
Cat # Size Price Quantity Check Availability Save
133804 100 µg £181.00
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

Mouse Decoy Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptor 1 (mDcTRAIL R1) is a GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain. It expresses on many cell types, including some tumor cells. mDcTRAIL R1 appears to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcR1 in apoptosis has not yet been clarified.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
mDcTRAIL-R1-Fc
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Bareiss PM, et al. 2013. Cancer Res. 73:5544. PubMed
Product Citations
  1. Knox T, et al. 2019. Sci Rep. 9:6136. PubMed
  2. Bareiss P, et al. 2013. Cancer Res. 73:5544. PubMed
RRID
AB_1626110 (BioLegend Cat. No. 133804)

Antigen Details

Structure
GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain.
Distribution
Express on many types of cells, including some tumor cells.
Function
Appear to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcR1 in apoptosis has not yet been clarified.
Ligand/Receptor
TRAIL
Molecular Family
Cytokine/Chemokine Receptors
Antigen References

1. Yagyu S, et al. 2008. Clin Cancer Res. 14 (21):7011
2. Ashkenazi A, et al. 1998. Science 281:1305

Gene ID
79201 View all products for this Gene ID
UniProt
View information about DcTRAIL R1 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Insert Note Here
Save Close Clear
Lab Timer
Tools
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account