PE anti-mouse CD160 Antibody

Pricing & Availability
Clone
7H1 (See other available formats)
Regulatory Status
RUO
Other Names
BY55, NK1, NK28
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
Cat # Size Price Quantity Check Availability Save
143003 25 µg £51.00
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143004 100 µg £133.00
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Description

CD160, also known as BY55, is a 27 kD glycoprotein and member of the Ig superfamily. It is anchored to the cell membrane through glycosylphosphatidylinositol (GPI) and forms disulfide-linked multimers. A soluble form of CD160 is secreted by activated CD8+ T cells. Expressed by NK, NKT, γ/δ T cells, intestinal intraepithelial T cells and a subset of memory CD8+ T cells, CD160 binds both classical and non-classical MHC class I molecules. It is also a ligand for HVEM. CD160 enhances proliferation of activated CD8+ T cells and triggers cell cytotoxicity in NK cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Soluble His-Tag mouse CD160
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Tsujimura K, et al. 2006. Immunol. Lett. 106:48. (FC)
Product Citations
  1. Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed
  2. Beltra JC, et al. 2020. Immunity. 52(5):825-841. PubMed
  3. Hudson WH, et al. 2020. Immunity. 51(6):1043-1058.e4.. PubMed
  4. RY H, et al. 2016. Oncoimmunology. 6:e1249561. PubMed
RRID
AB_10960740 (BioLegend Cat. No. 143003)
AB_10960743 (BioLegend Cat. No. 143004)

Antigen Details

Structure
Membrane glycoprotein, member of the Ig superfamily, 27 kD, glycosylphosphatidylinositol (GPI)-anchored, forms disulfide-linked multimers on the cell surface
Distribution
NK, NKT, γ/δT cells, intestinal intraepithelial T cells, subset of memory CD8+ T cells
Function
Enhances proliferation of activated CD8+ T cells, triggers cell cytotoxicity in NK cells
Ligand/Receptor
Classical and non-classical MHC-class I molecules, HVEM
Cell Type
NK cells, NKT cells, T cells
Biology Area
Immunology, Innate Immunity, Costimulatory Molecules
Molecular Family
CD Molecules, MHC Antigens, TCRs
Antigen References

1. Shui JW, et al. 2011. J. Leukoc. Biol. 89:517.
2. Del Rio ML, et al. 2010. J. Leukoc. Biol. 87:223.
3. Cai G and Freeman GJ. 2009. Immunol. Rev. 229:244.

Gene ID
54215 View all products for this Gene ID
UniProt
View information about CD160 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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