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PE anti-human uPA (PLAU) Antibody

Pricing & Availability
Clone
UK98/6 (See other available formats)
Regulatory Status
RUO
Other Names
Urokinase-type Plasminogen activator, urokinase, Plasminogen activator, ATF, BDPLT5, QPD, UPA, URK
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
UK98slash6_PE_uPa_Antibody_022416
Human lung cancer cell line H1299 cells were stained with u-PA (clone UK98/6) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • UK98slash6_PE_uPa_Antibody_022416
    Human lung cancer cell line H1299 cells were stained with u-PA (clone UK98/6) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
See PE spectral data
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369005 25 tests £100
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Description

uPA is a serine protease. It is produced as a single-chain protein containing serine protease domain, Kringle domain, and growth factor domain. It is proteolyticaly cleaved between Lys158 and Ile159; the two resulting chains are kept together as a dimer by a disulfide bond. The primary function of uPA is to convert plasminogen into plasmin by specific cleavage of an Arg-Val bond in plasminogen. uPA is also involved in the degradation of the extracellular matrix and possibly tumor cell migration and proliferation. Alternatively spliced transcript variants encoding different isoforms have been found for uPA; a specific polymorphism of uPA may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Purified urokinase
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Heidtmann H, et al. 1989. Cancer Research 49:6960.
  2. Schwartz-Albiez R, et al. 1992. Br. J. Cancer 65:51.
RRID
AB_2571974 (BioLegend Cat. No. 369005)

Antigen Details

Structure
411-aa residue zymogen that is cleaved into two chains and forms heterodimer.
Distribution

Urine, blood, and extracellular matrix.

Function
Serine protease.
Ligand/Receptor
u-PA Receptor, CD87.
Biology Area
Cell Adhesion, Cell Biology, Immunology
Antigen References

1. Riccio A, et al. 1985. Nucleic Acids Res. 13:2759.

Gene ID
5328 View all products for this Gene ID
UniProt
View information about uPA on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 02/24/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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