- MHN2-25 (See other available formats)
- Regulatory Status
- Other Names
- Neurogenic locus notch homolog protein 2, hN2, fN2
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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The Notch receptors are a type I transmembrane protein family that share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. They are highly conserved from invertebrates to mammals. Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors (Notch1-4). Notch1 and Notch 2 are reported to be functionally redundant. Notch 2 is expressed by Pre-B cells, double negative and CD8 single positive thymocytes, brain, lung cells. Notch 2 functions as a receptor for Jagged and Delta ligands, and may play a role in vascular, renal and hepatic development.Product Details
- Human, African Green
- Antibody Type
- Host Species
- Human Notch 2-human IgG1 Fc fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Haraguchi K, et al. 2009. J. Immunol. 182:6168.
- Product Citations
AB_2153620 (BioLegend Cat. No. 348303)
AB_2153619 (BioLegend Cat. No. 348304)
- Double negative and CD8 single positive thymocytes, pre-B cells, brain, lung
- Jag 1, Jag 2; Delta 1, Delta 4
- Cell Type
- Thymocytes, B cells, Neural Stem Cells
- Biology Area
- Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Antigen References
1. Haraguchi K, et al. 2009. J. Immunol. 182:6168.
2. O’Neill CF, et al.2007. Am. J. Path. 171:1023.
3. Bertrand FE, et al. 2000. Leukemia 14:2095.
- Gene ID
- 4853 View all products for this Gene ID
- View information about Notch 2 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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