- E6D7 (See other available formats)
- Regulatory Status
- Other Names
- Apolipoprotein E, apolipoprotein E3, AD2, LDLCQ5, LPG, ApoE
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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Apo-E is a class of apolipoprotein primarily synthesized in the liver, but is also found in other tissues such as brain, kidneys, and spleen. Apo-E is a protein component of serum chylomicron and lipoprotein particles, playing essential roles in cholesterol transportation, homeostasis, and metabolism. The expression of Apo-E is induced by cholesterol-rich diets and hyperlipoproteinemia. In the central nervous system, Apo-E is produced by astrocytes and microglia. The Apo-E-containing lipoprotein particles play important functions in brain injury repair, neurogenesis, and synaptic plasticity. Apo-E has been found to be involved in the regulation of amyloid-β aggregation and clearance. Genetic polymorphisms of Apo-E are associated with neuron degenerative disorders including Alzheimer's disease.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- This antibody was raised against a synthetic peptide corresponding to amino acids surrounding the polymorphic amino acid position 158 of Apo-E.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
This antibody is effective in immunoblotting (WB).
Clone E6D7 recognizes the E2, E3, and E4 isoforms of apolipoprotein E.
(PubMed link indicates BioLegend citation)
- Munoz DG, Feldman H. 2000. CMAJ. 162(1):65-72.
- Hagberg JM, et al. 2000. Physiol Genomics 4(2):101-108.
- Saunders AM. 2000. J. Neuropathol. Exp. Neurol. 59(9):751-8.
- Golabek AA, et al. 2000. Biophys. J. 79(2):1008-15.
- Zunarelli E, et al. 2000. Breast Cancer Res. Treat. 63(3):193-8.
- Zunarelli E, et al. 2000. Clin. Neuropathol. 19(1):1-6.
- Tomiyama T, et al. 1999. Cell Mol. Life Sci. 56(3-4):268-79.
- Golabek AA., et al. 1999. J. Biol. Chem. 271(18):10602-6.
AB_2801139 (BioLegend Cat. No. 803404)
AB_2801140 (BioLegend Cat. No. 803405)
- Cell Type
- Astrocytes, Mature Neurons, Microglia, Monocytes, Neurons, Oligodendrocytes
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Misfolding and Aggregation, Protein Trafficking and Clearance
- Molecular Family
- APP/Aβ Degradation, Apolipoproteins
- Gene ID
- 348 View all products for this Gene ID
- View information about Apo E on UniProt.org
Related Pages & Pathways
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other FormatsView All Apo E Reagents Request Custom Conjugation
|Purified anti-Apo E||E6D7||WB|
|PE anti-Apo E||E6D7||ICFC|
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