HRP anti-RAGE Antibody

Pricing & Availability
Clone
A17158D (See other available formats)
Other Names
RAGE, AGER, Advanced glycosylation end product-specific receptor
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
A17158D_HRP_RAGE_Antibody_012519
Western blot of HRP anti-RAGE antibody (clone A17158D). Lane 1: Molecular weight marker; Lane 2: 20 µg of human Lung lysate; The blot was incubated with 0.2 µg/mL of clone A17158D overnight at 4°C.Enhanced chemiluminescence (Cat. No. 426302) was used as the detection system.
  • A17158D_HRP_RAGE_Antibody_012519
    Western blot of HRP anti-RAGE antibody (clone A17158D). Lane 1: Molecular weight marker; Lane 2: 20 µg of human Lung lysate; The blot was incubated with 0.2 µg/mL of clone A17158D overnight at 4°C.Enhanced chemiluminescence (Cat. No. 426302) was used as the detection system.
Cat # Size Price Quantity Avail. Save
855903 25 µg £81
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855904 100 µg £178
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Description

RAGE (receptor for advanced glycation end products), is a member of the immunoglobulin super family of proteins with a molecular weight estimated at ~35 kD. RAGE is a pattern recognition receptor as it recognizes a common structure of a class of ligands, including HMGB1, S10012, S100B, S100A7, and amyloid precursor protein (APP).  RAGE may play a role in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). Increased RAGE expression levels have been observed in neurons and microglia surrounding senile plaques. In addition, RAGE can mediate the transport of amyloid beta across the blood-brain barrier and its accumulation in the brain.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant Human RAGE
Formulation
This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
Preparation
The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.05 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
RAGE is a 404 amino acid protein with an apparent molecular mass of ~43 kD.
Distribution

Tissue Distribution: Lung (major) and colon (less expressed)

Cellular Distribution: Plasma membrane, extracellular, and nucleus

Function
Functions as a pattern recognition receptor in the innate immune system that initiates proinflammatory responses.
Interaction
RAGE forms homo-dimers, and interacts with HMGB1, S100A1, APP, S100B, S100A12, and S100A14.
Ligand Receptor
AGEs (advanced glycation end-products)
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References
  1. Barbezier N, et al. 2014. Ann. Biol. Clin. (Paris) 72:669.
  2. Kalea AZ, et al. 2009. Clin. Sci. (Lond) 116:621.
Gene ID
177 View all products for this Gene ID
UniProt
View information about RAGE on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 01/25/2019

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