HRP anti-FXR1 Antibody

Pricing & Availability
Clone
6BG10 (See other available formats)
Other Names
FMR1 Autosomal Homolog 1, Fragile X Mental Retardation Syndrome-Related Protein 1
Isotype
Mouse IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
6BG10_HRP_FXR1_Antibody_100819
Western blot of HRP anti-FXR1 antibody (clone 6BG10). Lane 1: Molecular weight marker; Lane 2: 5 µg of human cerebellum lysate; Lane 3: 10 µg of human cerebellum lysate. The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C. Enhanced chemiluminescence was used as the detection system.
  • 6BG10_HRP_FXR1_Antibody_100819
    Western blot of HRP anti-FXR1 antibody (clone 6BG10). Lane 1: Molecular weight marker; Lane 2: 5 µg of human cerebellum lysate; Lane 3: 10 µg of human cerebellum lysate. The blot was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C. Enhanced chemiluminescence was used as the detection system.
Cat # Size Price Quantity Avail. Save
867003 25 µg £81
Check Availability


Need larger quantities of this item?
Request Bulk Quote
867004 100 µg £178
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

FXR1 is an RNA binding protein that interacts with polyribosomes, specifically with the 60S ribosome subunit. In the adult brain, FXR1 is mainly localized to the cytoplasm and the proximal dendrites of neurons. In the fetal brain, FXR1 is expressed in the nucleus of neurons. Clinically, FXR1 mutations have been identified as a major genetic contributing factor to fragile X mental retardation syndrome. Recent studies also suggest that FXR family of proteins integrate dopamine signaling and glutamatergic neurotransmission.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human FXR1
Formulation
This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
Preparation
The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
Concentration
0.5 mg/mL
Storage & Handling
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1.     Xu XL, et al. 2011. J. Neurosci. 31(39):13705-9. (WB)
  2.     Battle DJ, et al. 2007. J. Biol. Chem. 282(38):27953-9. (ICC)

Antigen Details

Structure
FXR1 is a 621 amino acid protein with predicted molecular mass of ~ 70 kD and observed molecular mass of ~ 75kD.
Distribution

Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Cytosol and nucleus

Function
FXR1 is an RNA binding protein involved in neurodevelopmental diseases such as autism, schizophrenia, and fragile X mental retardation.
Interaction
Polyribosome, FXR2, FMR1, CYFIP2
Cell Type
Dopaminergic Neurons, GABAergic Neurons, Neurons, Oligodendrocytes
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction, Synaptic Biology, Transcription Factors
Molecular Family
Postsynaptic proteins, Presynaptic proteins
Antigen References
  1.     Khlghatyan J, Beaulieu JM. 2018. Front Synaptic. Neurosci. 10:22.
  2.     Bardoni B, et al. 2001. Brain Res. Bull. 56:375-82.
  3.     Inoue SB, et al. 2000. J. Med. Invest. 47(3-4):101.
Gene ID
8087 View all products for this Gene ID
UniProt
View information about FXR1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 10/08/2019

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Login / Register
Forgot your password? Reset password?
Create an Account