- N388A/10 (See other available formats)
- Other Names
- ANK1, Ankyrin-R
- Mouse IgG2b, κ
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- Product Citations
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Ankyrin-R is an anchor protein whose main role in vivo is to anchor integral membrane protein/complexes to the cytoskeleton. It was originally discovered in erythrocytes, but later to be found expressed in the brain. The gene encoding Ankyrin-R, ANK1, has a highly complex regulatory mechanism, which gives rise to a variety of different isoforms of Ankyrin-R. Recent studies in Alzheimer’s Disease have shown that epigenetic dysregulation of ANK1, in combination of several other proteins including Trem-2, could be a contributing factor of increased TNFA expression and neuroinflammation1.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal condition
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Taylor A, et al. 2017. Front Cell Neurosci. 11:11 (IHC-F)
- Saifetiarova J, et al. 2017. J Neurosci. 37(10):2524 (IHC-F)
- Taylor A, et al. 2018. eNeuro. 5(3) (IHC-F, WB)
- ANK1 is a 1881 amino acid protein with an apparent molecular mass of ~ 206 kD.
Tissue Distribution: Brain and bone marrow.
Cellular Distribution: Plasma membrane, cytoskeleton, cytosol, nucleus, and endoplasmic reticulum.
- ANK1 functions as an adaptor protein to anchor integral membrane proteins/complexes to the cytoskeleton.
- SPTB, SLC4A1, EPB41, TTN, OBSCN, HIF1AN
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Adaptor Proteins
- Antigen References
- Morris G, et al. 2018. Mol Neurobiol. doi: 10.1007/s12035-018-1092-y.
- Nicolas V, et al. 2006. Transfuse Clin Biol. 13(1-2):23
- Kline CF, et al. 2006. Expert Rev Cardiovasc Ther. 4(4):477
- Gene ID
- 286 View all products for this Gene ID 11733 View all products for this Gene ID 306570 View all products for this Gene ID
- View information about Ankyrin-R on UniProt.org
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