- 3.2.3 (See other available formats)
- Other Names
- NKR-P1, CD161a/CD161b, NKR-P1a/KLRB1a
- Mouse IgG1, κ
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- Product Citations
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CD161 is a 30 kD type II transmembrane C-type lectin, expressed as a homodimer. Rat NKR-P1 receptors are primarily expressed on NK cells, a subset of T cells, dendritic cells, and activated monocytes. There are three different types of NKR-P in rat, namely NKR-P1a, NKR-P1b, and NKR-P1c. NKR-P1a does not contain an ITIM structure and is an activating receptor, while NKR-P1b contains an ITIM and displays inhibitory function. LLT-1 (ligand lectin like transcript 1) is the ligand, while KLR (killer cell lectin like) functions as a receptor.Product Details
- Antibody Type
- Host Species
- LEW rat splenic NK cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
3.2.3 recognizes a common epitope of NKR-1P1a (CD161a) and NKR-P1b (CD161b).
(PubMed link indicates BioLegend citation)
- Chambers W, et al. 1989. J. Exp. Med. 169:1373. (FC)
AB_2564547 (BioLegend Cat. No. 205608)
- Type II transmembrane C-type lectin, 30 kD.
- NK cells, subset of T cells, dendritic cells, activated monocytes.
- NKR-P1a is a NK cell-activating receptor; NKR-P1b is a NK cell-inhibitory receptor.
- LLT1-ligand lectin like transcript 1; KLR-killer cell lectin like receptor.
- Cell Type
- NK cells, T cells, Dendritic cells, Monocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- CD Molecules
- Antigen References
1. Chambers WH, et al. 1989. J. Exp. Med. 169:1373.
2. Brink M, et al. 1990. J. Exp. Med. 171:197.
3. Li J, et al. 2003. Int. Immunol. 15:411.
- Gene ID
- 362443 View all products for this Gene ID
- View information about CD161 on UniProt.org
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