FITC anti-mouse CD206 (MMR) Antibody

Pricing & Availability
C068C2 (See other available formats)
Regulatory Status
Other Names
MMR (macrophage mannose receptor), MR (mannose receptor), MRC1
Rat IgG2a, κ
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Product Citations
Thioglycollate-elicited Balb/c macrophages were fixed/pemeabilized, and then stained with CD107b (Mac-3) APC and CD206 (clone C068C2) FITC (top) or rat IgG2a, κ FITC isotype control (bottom).
  • C068C2_FITC_1_072111
    Thioglycollate-elicited Balb/c macrophages were fixed/pemeabilized, and then stained with CD107b (Mac-3) APC and CD206 (clone C068C2) FITC (top) or rat IgG2a, κ FITC isotype control (bottom).
  • C068C2_FITC_2_072111
Compare all formats See FITC spectral data
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141703 50 µg £94
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141704 200 µg £221
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CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Recombinant mouse CD206 (MMR)
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

ICFC - Quality tested
FC - Verified

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Clone C068C2 recognizes a region similar to clone MR5D3, based on the ability of the clones to block each other. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)4,5.

Application References

(PubMed link indicates BioLegend citation)
  1. Keller J, et al. 2012. Biochem Biophys Res Commun. 417:217. PubMed
  2. Ito H, et al. 2012. J Am Soc Nephrol. 23:1797. PubMed
  3. Yang X, et al. 2015. PNAS. 112:2900. PubMed
  4. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  5. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Oliver AJ, et al. 2020. Oncoimmunology. 9:1802979. PubMed
  2. Liang S, et al. 2019. Mol Med Rep. 19:3707. PubMed
  3. Valanparambil RM, et al. 2017. PLoS Pathog. 13:e1006647. PubMed
  4. Sun L, et al. 2021. Cancer Cell. :. PubMed
  5. Meng W, et al. 2021. JCI Insight. 6:. PubMed
  6. Miao L, et al. 2020. Theranostics. 0.7625. PubMed
  7. Keane T, et al. 2012. Biomaterials. 33:1771. PubMed
  8. Kesavan R, et al. 2021. Int J Mol Sci. 22:. PubMed
  9. Zakeri A, et al. 2021. J Extracell Vesicles. 10:e12131. PubMed
  10. Choi B, et al. 2017. Eur J Pharmacol. 10.1016/j.ejphar.2017.07.022. PubMed
  11. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  12. Li C, et al. 2022. Theranostics. 12:4581. PubMed
  13. Ma C, et al. 2022. Proc Natl Acad Sci U S A. 119:. PubMed
  14. Zhang W, et al. 2021. Front Immunol. 12:688294. PubMed
  15. Wada I, et al. 2021. Invest Ophthalmol Vis Sci. 62:17. PubMed
  16. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  17. Eastman A, et al. 2016. J Immunol . 194: 5999-6010. PubMed
  18. Lee S, et al. 2015. PLoS One. 10: 0132329. PubMed
  19. Hindi S, et al. 2012. Mol Cell Biol. 32:4833. PubMed
  20. Li H, et al. 2019. J Immunol Res. 2018:4807145. PubMed
  21. Song M, et al. 2021. J Immunol Res. 6696606:2021. PubMed
  22. Uroda T, et al. 2020. Nat Protoc. 15:2107. PubMed
  23. Li K, et al. 2022. J Immunother Cancer. 10:. PubMed
  24. Yang Y, et al. 2022. Regen Biomater. 9:rbac023. PubMed
  25. Forni MF, et al. 2021. Front Oncol. 11:667715. PubMed
  26. Ma J, et al. 2021. Curr Protoc. 1:e144. PubMed
  27. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  28. Amo-Aparicio J, et al. 2021. Theranostics. 11:9805. PubMed
  29. Li Z, et al. 2022. J Exp Clin Cancer Res. 41:74. PubMed
  30. Guo L, et al. 2021. Front Immunol. 12:785457. PubMed
  31. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  32. Nguyen TKT, et al. 2020. Am J Pathol. 286:190. PubMed
  33. Yin S, et al. 2016. Nat Commun. 7: 11311. PubMed
  34. Yin T, et al. 2016. Sci Rep. 18:19534. PubMed
  35. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  36. Lee SS, et al. 2022. Commun Biol. 5:654. PubMed
  37. Zhang F, et al. 2017. Mol Immunol. 10.1016/j.molimm.2017.06.019. PubMed
  38. Vigeland C, et al. 2016. PLoS One. 11: 0163288. PubMed
  39. Lu CS, et al. 2020. J Hematol Oncol. 0.584722222. PubMed
  40. Li N, et al. 2021. eLife. 10:00. PubMed
  41. Neupane AS, et al. 2020. Cell. 183(1):110-125.e11. PubMed
  42. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  43. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  44. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  45. Sun L, et al. 2015. J Immunol. 194:4891. PubMed
  46. Kida Y, et al. 2013. J Am Soc Nephrol. 24:559. PubMed
  47. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  48. Ishii H, et al. 2012. Cell Death Dis. 9;3:e363. PubMed
  49. Lu J, et al. 2021. Cell Death Discov. 7:165. PubMed
  50. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  51. Zhou T, et al. 2022. Sci Adv. 8:eabj9617. PubMed
  52. Guan X, et al. 2022. Nat Commun. 13:2834. PubMed
  53. Galle-Treger L, et al. 2019. Nat Commun. 10:713. PubMed
  54. Genoula M, et al. 2018. Front Immunol. 9:459. PubMed
  55. Zimmerman KA, et al. 2019. J Am Soc Nephrol. 30:1841. PubMed
  56. Yang Y, et al. 2020. Cancer Biol Ther. 522:21. PubMed
  57. Miki Y, et al. 2022. JCI Insight. 7:. PubMed
  58. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  59. Ano Y, et al. 2019. Nutrients. 1.959027778. PubMed
  60. Shibata T, et al. 2020. J Clin Invest. 130:3021. PubMed
  61. Li Y, et al. 2015. Sci Rep. 5: 18648. PubMed
  62. Makino A, et al. 2021. iScience. 24:103201. PubMed
  63. Wang S, et al. 2022. J Inflamm Res. 14:7107. PubMed
  64. Laban H, et al. 2018. J Cell Biol. 217:1503. PubMed
  65. Liu Y, et al. 2015. BioMed Res Int. 2015 563425. PubMed
  66. Shen L, et al. 2016. Sci Rep. 6:30347. PubMed
  67. Cuccarese M, et al. 2017. Nat Commun. 8:14293. PubMed
  68. Yuan Y, et al. 2020. Front Physiol. 0.967361111. PubMed
  69. Wang X, et al. 2021. Cell. 184:5357. PubMed
  70. de Assis LVM, et al. 2022. Commun Biol. 5:461. PubMed
  71. Grayczyk JP et al. 2017. Cell host & microbe. 22(5):678-687 . PubMed
  72. Kaji T, et al. 2012. J Exp Med. 80:3642. PubMed
  73. Wang D, et al. 2021. Nan Fang Yi Ke Da Xue Xue Bao. 41:775. PubMed
  74. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  75. Madsen CS, et al. 2022. Commun Biol. 5:888. PubMed
  76. Wang S, et al. 2020. J Cell Mol Med. 24:722. PubMed
  77. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  78. McAusland TM, et al. 2021. Mol Ther Oncolytics. 20:306. PubMed
  79. Medina-Buelvas DM, et al. 2021. Pathogens. 10:. PubMed
  80. Gao R, et al. 2021. J Clin Invest. 131:. PubMed
  81. Fransén Pettersson N, et al. 2018. PLoS One. 13:e0203228. PubMed
  82. Hartwig T et al. 2017. Molecular cell. 65(4):730-742 . PubMed
  83. Gu L, et al. 2017. FASEB J. 31:3072. PubMed
  84. Perrotta C, et al. 2018. Front Immunol. 9:1186. PubMed
  85. Chen Y, et al. 2021. Cancer Cell. 39(4):548-565.e6. PubMed
  86. Xue YL, et al. 2020. J Cell Mol Med. 24:12341. PubMed
  87. Zhang J, et al. 2014. J Immunol. 193:5149. PubMed
  88. Kim YD, et al. 2020. J Cancer. 11:4059. PubMed
  89. Chen Z, et al. 2016. Innate Immunity. 22: 419 - 432. PubMed
  90. Hall JA, et al. 2020. Cell Metabolism. 32(4):665-675.e6. PubMed
  91. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  92. Scheyltjens I, et al. 2022. Nat Protoc. 17:2354. PubMed
  93. Xue Y, et al. 2020. Sci Rep. 10:22265. PubMed
  94. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  95. Yuan C, et al. 2020. Braz J Med Biol Res. 53:e9488. PubMed
  96. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  97. Li J, et al. 2021. eLife. 10:00. PubMed
  98. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  99. Yao Y, et al. 2016. Mol Ther. 10.1038/mt.2016.36. PubMed
AB_10900988 (BioLegend Cat. No. 141703)
AB_10901166 (BioLegend Cat. No. 141704)

Antigen Details

Type I transmembrane protein, 175 kD, C-type lectin superfamily

Macrophages, dendritic cells, Langerhans cells, liver endothelial cells

Pathogen recognition, endocytosis and phagocytosis, antigen presentation
Antigen containing mannose, fucose, or an N-acetyl glucosamine
Cell Type
Dendritic cells, Endothelial cells, Langerhans cells, Macrophages
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.

Gene ID
17533 View all products for this Gene ID
View information about CD206 on

Related FAQs

Why is mouse CD206 stained intracellularly and not via surface staining?

Typically, mouse CD206 surface level is relatively low under normal conditions and so intracellular staining protocol is required to get better signal.

Go To Top Version: 4    Revision Date: 04/04/2016

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Biotin anti-mouse CD206 (MMR)

  • Purified anti-mouse CD206 (MMR)

  • FITC anti-mouse CD206 (MMR)

  • PE anti-mouse CD206 (MMR)

  • APC anti-mouse CD206 (MMR)

  • Alexa Fluor® 488 anti-mouse CD206 (MMR)

  • Alexa Fluor® 647 anti-mouse CD206 (MMR)

  • PerCP/Cyanine5.5 anti-mouse CD206 (MMR)

  • PE/Cyanine7 anti-mouse CD206 (MMR)

  • Brilliant Violet 421™ anti-mouse CD206 (MMR)

  • Brilliant Violet 605™ anti-mouse CD206 (MMR)

  • Brilliant Violet 650™ anti-mouse CD206 (MMR)

  • Alexa Fluor® 594 anti-mouse CD206 (MMR)

  • Brilliant Violet 711™ anti-mouse CD206 (MMR)

  • Brilliant Violet 785™ anti-mouse CD206 (MMR)

  • PE/Dazzle™ 594 anti-mouse CD206 (MMR)

  • Alexa Fluor® 700 anti-mouse CD206 (MMR)

  • Spark YG™ 570 anti-mouse CD206 (MMR)

  • PE/Cyanine5 anti-mouse CD206 (MMR)

  • PE/Fire™ 700 anti-mouse CD206 (MMR)


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