- VIM3b (See other available formats)
- Regulatory Status
- V BP030
- Other Names
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD97 is a seven-span transmembrane protein belonging to the secretin receptor superfamily, the G-protein-coupled receptor superfamily, and the EGF-TM7 family with molecular weights of 74 kD, 80 kD, and 86 kD. It is expressed on monocytes/macrophages, granulocytes, dendritic cells, and smooth muscle cells.The expression of CD97 on resting T- and B-lymphocytes is at low level, but is rapidly upregulated upon activation. CD97 binds to CD55 (decay-accelerating factor), chondroitin sulfate, integrin a5b1, and a3b1. CD97 has been shown to mediate cell adhesion and co-stimulation of T cell proliferation.Product Details
- Verified Reactivity
- Reported Reactivity
- Antibody Type
- Host Species
- KG1a (human myeloid cell line)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
Clone VIM3b bindswithin the first EGF domain of CD97.4 Additional reported applications include: western blot, immunoprecipitation.
(PubMed link indicates BioLegend citation)
- Hamann J, et al. 1995. J. Immunol. 155:1942.
- Lawrence DW, et al. 2003. J. Exp. Med. 198:999.
- Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
- Wobus M, et al. 2004. Int. J. Cancer 112:815.
- Product Citations
AB_1227610 (BioLegend Cat. No. 336305)
AB_1227609 (BioLegend Cat. No. 336306)
- Seven-span transmembrane protein belonging to the secretin receptor superfamily, the G-protein-coupled receptor superfamily, and the EGF-TM7 family, 74 kD, 80 kD, 86 kD
Monocytes/macrophages, granulocytes, dendritic cells, low levels on T cells and B-lymphocytes and upregulated upon activation
- Co-stimulation, adhesion
- CD55, chondroitin sulfate, integrin α5β1, integrin α3β1
- Cell Type
- Dendritic cells, Granulocytes, Macrophages, Monocytes
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Capasso M, et al. 2006. J. Immunol. 177:1070
2. Wang T, et al. 2005. Blood 105:2836
3. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. A John Wiley & Sons Inc, Publication
- Gene ID
- 976 View all products for this Gene ID
- View information about CD97 on UniProt.org
|FITC anti-human CD97||VIM3b||FC|
|PE anti-human CD97||VIM3b||FC|
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