- OX-62 (See other available formats)
- Regulatory Status
- Other Names
- Integrin αE, integrin E, integrin αIEL, integrin αOX-62, Itgae
- Mouse IgG1
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- Product Citations
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CD103, also known as Integrin αE or integrin αIEL, is a single pass transmembrane protein composed by two chains, heavy and light, linked by a disulfide bond. It is expressed in the cell surface as an αE/β7 heterodimer. CD103 mediates adhesion of intraepithelial T cells (IEL) to the epithelium. CD103 is expressed by IEL, effector and memory Tregs, and dendritic cells and their immediate precursors. E-cadherin is the ligand for CD103.Product Details
- Antibody Type
- Host Species
- Density gradient enriched lymph veiled cells from PVG rats
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of frozen skin and intestine epithelium1,4, immunocytochemical staining of cytospin preparations4, and Western blot1.
(PubMed link indicates BioLegend citation)
- Brenan M, et al. 1992. J. Exp. Med. 175:1457. (IHC, WB)
- Chen-Woan M, et al. 1995. J. Immunol. Methods 178:157.
- Chen-Woan M, et al. 1996. J. Leuk. Biol. 59:196.
- Brenan M and Rees DJ. 2000. Eur. J. Immunol. 30:1527. (IHC)
AB_10683166 (BioLegend Cat. No. 205503)
- Single pass transmembrane protein, composed by two chains, heavy and light, linked by a disulfide bond. Associates with integrin β7 to form the αE/β7 complex.
Intraepithelial T lymphocytes, effector and memory Tregs, dendritic cells and their immediate precursors.
- Mediates adhesion of intraepithelial T cells (IEL) to epithelium.
- Cell Type
- Dendritic cells, T cells, Tregs
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroscience, Synaptic Biology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Varas A, et al. 1998. Blood 92:93.
2. Brissette-Storkus CS, et al. 2002. J. Leukoc. Biol. 71:941.
3. Hubert FX, et al. 2004. J. Immunol. 172:7485.
4. Tsuchihashi S, et al. 2006. J. Immunol. 176:616.
5. Lührmann A, et al. 2007. Immunol. Lett. 108:167.
- Gene ID
- 83577 View all products for this Gene ID
- View information about CD103 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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